ArticleBiophysical journal2011
The endocochlear potential alters cochlear micromechanics.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Perilymphatic ATP plays a critical role in modulating cochlear function to protect from loud sound induced hearing loss.EBioMedicine · 2026Article
- The Cochlear Lateral Wall as a Biological Battery: the Mechanisms Underlying KJournal of the Association for Research in Otolaryngology : JARO · 2026Review
- The tectorial membrane has a critical role in metabolic age-related hearing loss.EBioMedicine · 2025Article
- Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil.Hearing research · 2021Article
- Inner hair cell stereocilia are embedded in the tectorial membrane.Nature communications · 2021Article
- Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets.Frontiers in molecular neuroscience · 2021Article
- Radixin modulates the function of outer hair cell stereocilia.Communications biology · 2020Article
- Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity.Biophysical journal · 2020Article
- Characterisation of the static offset in the travelling wave in the cochlear basal turn.Pflugers Archiv : European journal of physiology · 2020Article
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- Adaptation of Cochlear Amplification to Low Endocochlear Potential.Biophysical journal · 2019Article
- Control of hearing sensitivity by tectorial membrane calcium.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ.Nature communications · 2018Article
- Static length changes of cochlear outer hair cells can tune low-frequency hearing.PLoS computational biology · 2018Article
- Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear.Frontiers in molecular neuroscience · 2017Article
- The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.Pflugers Archiv : European journal of physiology · 2016Review
- Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins.PLoS genetics · 2015Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
- Basilar membrane and tectorial membrane stiffness in the CBA/CaJ mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acoustic stimulation gates mechanically sensitive ion channels in cochlear sensory hair cells. Even in the absence of sound, a fraction of these channels remains open, forming a conductance between hair cells and the adjacent fluid space, scala media. Restoring the lost endogenous polarization of scala media in an in vitro preparation of the whole cochlea depolarizes the hair cell soma. Using both digital laser interferometry and time-resolved confocal imaging, we show that this causes a structural refinement within the organ of Corti that is dependent on the somatic electromotility of the outer hair cells (OHCs). Specifically, the inner part of the reticular lamina up to the second row of OHCs is pulled toward the basilar membrane, whereas the outer part (third row of OHCs and the Hensen's cells) unexpectedly moves in the opposite direction. A similar differentiated response pattern is observed for sound-evoked vibrations: restoration of the endogenous polarization decreases vibrations of the inner part of the reticular lamina and results in up to a 10-fold increase of vibrations of the outer part. We conclude that the endogenous polarization of scala media affects the function of the hearing organ by altering its geometry, mechanical and electrical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.