ArticleBiophysical journal2011
Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current.Scientific reports · 2024Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- Something in Our Ears Is Oscillating, but What? A Modeller's View of Efforts to Model Spontaneous Emissions.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Radixin modulates the function of outer hair cell stereocilia.Communications biology · 2020Article
- Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.Scientific reports · 2019Article
- Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea.eLife · 2019Article
- Probing hair cell's mechano-transduction using two-tone suppression measurements.Scientific reports · 2019Article
- The Competition between the Noise and Shear Motion Sensitivity of Cochlear Inner Hair Cell Stereocilia.Biophysical journal · 2018Article
- Modeling signal propagation in the human cochlea.The Journal of the Acoustical Society of America · 2017Article
- Negative membrane capacitance of outer hair cells: electromechanical coupling near resonance.Scientific reports · 2017Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Two passive mechanical conditions modulate power generation by the outer hair cells.PLoS computational biology · 2017Article
- Simulating the Chan-Hudspeth experiment on an active excised cochlear segment.The Journal of the Acoustical Society of America · 2017Article
- Analytical and numerical modeling of the hearing system: Advances towards the assessment of hearing damage.Hearing research · 2017Review
- Finite-element model of the active organ of Corti.Journal of the Royal Society, Interface · 2016Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
- Modeling auditory coding: from sound to spikes.Cell and tissue research · 2015Review
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2 authors.
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Abstract
One of the central questions in the biophysics of the mammalian cochlea is determining the contributions of the two active processes, prestin-based somatic motility and hair bundle (HB) motility, to cochlear amplification. HB force generation is linked to fast adaptation of the transduction current via a calcium-dependent process and somatic force generation is driven by the depolarization caused by the transduction current. In this article, we construct a global mechanical-electrical-acoustical mathematical model of the cochlea based on a three-dimensional fluid representation. The global cochlear model is coupled to linearizations of nonlinear somatic motility and HB activity as well as to the micromechanics of the passive structural and electrical elements of the cochlea. We find that the active HB force alone is not sufficient to power high frequency cochlear amplification. However, somatic motility can overcome resistor-capacitor filtering by the basolateral membrane and deliver sufficient mechanical energy for amplification at basal locations. The results suggest a new theory for high frequency active cochlear mechanics, in which fast adaptation controls the transduction channel sensitivity and thereby the magnitude of the energy delivered by somatic motility.
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