ArticleBiophysical journal2011
Orientation and polarity in collectively migrating cell structures: statics and dynamics.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Clusters, fingers, and singles: A mechanical landscape of tumor invasion.PLoS computational biology · 2026Article
- A Microfabricated Branch Selection Platform for Quantitative Measurement of Leader-Follower Interaction Strength and Interaction Range in Collective Cell Migration.Micromachines · 2026Article
- Collective behavior of "flexicles".Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Traction and Stress Control Formation and Motion of +1/2 Topological Defects in Epithelial Cell Monolayers.Newton ((New York, N.Y.) · 2025Article
- Cytoskeletal mechanics in collective cell migration.Biophysical journal · 2025Article
- Geometrical constraint change determines organized collective migration of follower cells.Scientific reports · 2025Article
- Article
- A deep learning-based pipeline for analyzing the influences of interfacial mechanochemical microenvironments on spheroid invasion using differential interference contrast microscopic images.Materials today. Bio · 2023Article
- Article
- The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces.Science advances · 2022Article
- Dominant geometrical factors of collective cell migration in flexible 3D gelatin tube structures.Biophysical reports · 2022Article
- Modes of information flow in collective cohesion.Science advances · 2022Article
- Low-intensity continuous ultrasound to inhibit cancer cell migration.Frontiers in cell and developmental biology · 2022Article
- Photothermal Agarose Microfabrication Technology for Collective Cell Migration Analysis.Micromachines · 2021Article
- Article
- Transfer entropy dependent on distance among agents in quantifying leader-follower relationships.Biophysics and physicobiology · 2021Article
- Fabrication of tough, anisotropic, chemical-crosslinker-free poly(vinyl alcohol) nanofibrous cryogelsRSC advances · 2020Article
- Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the absence of growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Topographical curvature is sufficient to control epithelium elongation.Scientific reports · 2020Article
- Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia.eLife · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collective cell migration is often characterized by the spontaneous onset of multicellular protrusions (known as fingers) led by a single leader cell. Working with epithelial Madin-Darby canine kidney monolayers we show that cells within the fingers, as compared with the epithelium, are well oriented and polarized along the main finger direction, which suggests that these cells actively migrate. The cell orientation and polarity decrease continuously from the tip toward the epithelium over a penetration distance of typically two finger lengths. Furthermore, laser photoablation experiments at various locations along these fingers demonstrate that the cells in the fingers are submitted to a tensile stress whose value is larger close to the tip. From a dynamical point of view, cells entering a finger gradually polarize on timescales that depend upon their particular initial position. Selective laser nanosurgery of the leader lamellipodium shows not only that these structures need a leader to progress, but that this leader itself is the consequence of a prior self-organization of the cells forming the finger. These results highlight the complex interplay between the collective orientation within the fingers and the mechanical action of the leader.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.