ArticleBiophysical journal2011
Robust entrainment of circadian oscillators requires specific phase response curves.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Entrainment and multi-stability of the p53 oscillator in human cells.Cell systems · 2024Article
- Optimal synchronization in pulse-coupled oscillator networks using reinforcement learning.PNAS nexus · 2023Article
- An effective model of endogenous clocks and external stimuli determining circadian rhythms.Scientific reports · 2021Article
- A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light.Scientific reports · 2021Article
- Complementary phase responses via functional differentiation of dual negative feedback loops.PLoS computational biology · 2021Article
- Coupling protocol of interlocked feedback oscillators in circadian clocks.Journal of the Royal Society, Interface · 2020Article
- Feeding Rhythms and the Circadian Regulation of Metabolism.Frontiers in nutrition · 2020Review
- A saturated reaction in repressor synthesis creates a daytime dead zone in circadian clocks.PLoS computational biology · 2019Article
- Synchronization of pancreatic islets by periodic or non-periodic muscarinic agonist pulse trains.PloS one · 2019Article
- Modeling Reveals a Key Mechanism for Light-Dependent Phase Shifts of Neurospora Circadian Rhythms.Biophysical journal · 2018Article
- Period Robustness and Entrainability of the Kai System to Changing Nucleotide Concentrations.Biophysical journal · 2017Article
- Article
- Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments.PLoS computational biology · 2016Article
- Punctual transcriptional regulation by the rice circadian clock under fluctuating field conditions.The Plant cell · 2015Article
- Velocity response curves demonstrate the complexity of modeling entrainable clocks.Journal of theoretical biology · 2014Article
- Amplitude metrics for cellular circadian bioluminescence reporters.Biophysical journal · 2014Article
- Period doubling induced by thermal noise amplification in genetic circuits.Scientific reports · 2014Article
- An energy-optimal approach for entrainment of uncertain circadian oscillators.Biophysical journal · 2014Article
- Circadian clocks optimally adapt to sunlight for reliable synchronization.Journal of the Royal Society, Interface · 2014Article
- Adaptive temperature compensation in circadian oscillations.PLoS computational biology · 2012Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The circadian clocks keeping time in many living organisms rely on self-sustained biochemical oscillations entrained by external cues, such as light, to the 24-h cycle induced by Earth's rotation. However, environmental cues are unreliable due to the variability of habitats, weather conditions, or cue-sensing mechanisms among individuals. A tempting hypothesis is that circadian clocks have evolved so as to be robust to fluctuations in the signal that entrains them. To support this hypothesis, we analyze the synchronization behavior of weakly and periodically forced oscillators in terms of their phase response curve (PRC), which measures phase changes induced by a perturbation applied at different times of the cycle. We establish a general relationship between the robustness of key entrainment properties, such as stability and oscillator phase, on the one hand, and the shape of the PRC as characterized by a specific curvature or the existence of a dead zone, on the other hand. The criteria obtained are applied to computational models of circadian clocks and account for the disparate robustness properties of various forcing schemes. Finally, the analysis of PRCs measured experimentally in several organisms strongly suggests a case of convergent evolution toward an optimal strategy for maintaining a clock that is accurate and robust to environmental fluctuations.
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