ArticleBiophysical journal2011
Theoretical and computational investigation of flagellin translocation and bacterial flagellum growth.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Uncovering the Kinetic Characteristics and Degradation Preference of PROTAC Systems with Advanced Theoretical Analyses.JACS Au · 2023Article
- Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure.International journal of molecular sciences · 2021Review
- Protein Export via the Type III Secretion System of the Bacterial Flagellum.Biomolecules · 2021Review
- Bacterial Vivisection: How Fluorescence-Based Imaging Techniques Shed a Light on the Inner Workings of Bacteria.Microbiology and molecular biology reviews : MMBR · 2020Review
- Multiple Flagellin Proteins Have Distinct and Synergistic Roles in Agrobacterium tumefaciens Motility.Journal of bacteriology · 2018Article
- Molecular dynamics simulation of bacterial flagella.Biophysical reviews · 2018Review
- The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5.PLoS pathogens · 2017Article
- Article
- Length-dependent flagellar growth ofeLife · 2017Article
- Type III secretion systems: the bacterial flagellum and the injectisome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- A chain mechanism for flagellum growth.Nature · 2013Article
- Single-file diffusion of flagellin in flagellar filaments.Biophysical journal · 2013Article
- Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).Nature communications · 2013Article
- Growth of flagellar filaments of Escherichia coli is independent of filament length.Journal of bacteriology · 2012Article
- Parallel Generalized Born Implicit Solvent Calculations with NAMD.Journal of chemical theory and computation · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The bacterial flagellum is a self-assembling filament, which bacteria use for swimming. It is built from tens of thousands of flagellin monomers in a self-assembly process that involves translocation of the monomers through the flagellar interior, a channel, to the growing tip. Flagellum monomers are pumped into the filament at the base, move unfolded along the channel and then bind to the tip of the filament, thereby extending the growing flagellum. The flagellin translocation process, due to the flagellum maximum length of 20 μm, is an extreme example of protein transport through channels. Here, we derive a model for flagellin transport through the long confining channel, testing the key assumptions of the model through molecular dynamics simulations that also furnish system parameters needed for quantitative description. Together, mathematical model and molecular dynamics simulations explain why the growth rate of flagellar filaments decays exponentially with filament length and why flagellum growth ceases at a certain maximum length.
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Registered trials
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