ArticleBiophysical journal2011
Viral capsid equilibrium dynamics reveals nonuniform elastic properties.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Article
- Post-buckling of a pressured biopolymer spherical shell with the mode interaction.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Why Enveloped Viruses Need Cores-The Contribution of a Nucleocapsid Core to Viral Budding.Biophysical journal · 2018Article
- Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles.PLoS computational biology · 2016Article
- Recent Developments in Molecular Simulation Approaches to Study Spherical Virus Capsids.Molecular simulation · 2014Article
- Collective variable approaches for single molecule flexible fitting and enhanced sampling.Chemical reviews · 2014Review
- Structural transitions and energy landscape for Cowpea Chlorotic Mottle Virus capsid mechanics from nanomanipulation in vitro and in silico.Biophysical journal · 2013Article
- Modeling and simulation of the mechanical response from nanoindentation test of DNA-filled viral capsids.Journal of biological physics · 2013Article
- Integrin and defensin modulate the mechanical properties of adenovirus.Journal of virology · 2013Article
- On the morphology of viral capsids: elastic properties and buckling transitions.The journal of physical chemistry. B · 2012Article
- Mechanics of bacteriophage maturation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.Biophysical journal · 2012Article
- Modeling Viral Capsid Assembly.Advances in chemical physicsArticle
- Equilibrium mechanisms of self-limiting assembly.Reviews of modern physicsArticle
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Authors and funding
4 authors.
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Abstract
The long wavelength, low-frequency modes of motion are the relevant motions for understanding the continuum mechanical properties of biomolecules. By examining these low-frequency modes, in the context of a spherical harmonic basis set, we identify four elastic moduli that are required to describe the two-dimensional elastic behavior of capsids. This is in contrast to previous modeling and theoretical studies on elastic shells, which use only the two-dimensional Young's modulus (Y) and the bending modulus (κ) to describe the system. Presumably, the heterogeneity of the structure and the anisotropy of the biomolecular interactions lead to a deviation from the homogeneous, isotropic, linear elastic shell theory. We assign functional relevance of the various moduli governing different deformation modes, including a mode primarily sensed in atomic force microscopy nanoindentation experiments. We have performed our analysis on the T = 3 cowpea chlorotic mottle virus and our estimate for the nanoindentation modulus is in accord with experimental measurements.
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