Evidence map›Paper›PMID 21640742›Full record

ArticleTheoretical population biology2011

Mathematical properties of Fst between admixed populations and their parental source populations.

Simina M Boca, Noah A Rosenberg

Abstract read
In one paragraph

Article in Theoretical population biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  4. Genetic landscape of Gullah African Americans.American journal of physical anthropology · 2021
    Article
  5. Article
  6. On the heterozygosity of an admixed population.Journal of mathematical biology · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The behavior of admixed populations in neighbor-joining inference of population trees.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Simina M BocaDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA. sboca@jhsph.edu
Noah A Rosenberg

Funding

Population genetics for large-scale sequencing studies of diverse populationsR01HG005855 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Noah Rosenberg, Paul A Scheet · 2010 to 2026
$5.8M
Population-Genetic Studies for Association MappingR01GM081441 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSENBERG, NOAH · 2007 to 2011
$1.7M
Predoctoral Biostatistics Training in Genetics/GenomicsT32GM074906 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2006 to 2010
$905k
NHGRI NIH HHS R01 HG005855NIGMS NIH HHS R01 GM081441NIGMS NIH HHS T32 GM074906
6 · The paper itself

Abstract

We consider the properties of the F(st) measure of genetic divergence between an admixed population and its parental source populations. Among all possible populations admixed among an arbitrary set of parental populations, we show that the value of F(st) between an admixed population and a specific source population is maximized when the admixed population is simply the most distant of the other source populations. For the case with only two parental populations, as a function of the admixture fraction, we further demonstrate that this F(st) value is monotonic and convex, so that F(st) is informative about the admixture fraction. We illustrate our results using example human population-genetic data, showing how they provide a framework in which to interpret the features of F(st) in admixed populations.

Indexed as

Genetics, PopulationModels, TheoreticalParentsHumans

Identifiers

PMID21640742
PMCPMC3206961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.