ArticleExperimental and molecular pathology2011
Delta-aminolevulinic dehydratase is a proteasome interacting protein.
Article in Experimental and molecular pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Milestones in the Elucidation of Heme Biosynthesis.Chemical reviews · 2026Review
- Peste des petits ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue.Microbiology spectrum · 2025Article
- Neem leaf powder (Azadirachta indica) mitigates oxidative stress and pathological alterations triggered by lead toxicity in Nile tilapia (Oreochromis niloticus).Scientific reports · 2023Article
- Unravelling the Initial Triggers ofJournal of fungi (Basel, Switzerland) · 2021Article
- Exoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile from Latin America reveal close similarities.Scientific reports · 2021Article
- An eleven metabolic gene signature-based prognostic model for clear cell renal cell carcinoma.Aging · 2020Article
- Genetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach.Scientific reports · 2020Article
- Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms.Frontiers in molecular biosciences · 2019Review
- The Remarkable Character of Porphobilinogen Synthase.Accounts of chemical research · 2016Article
- Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.Experimental gerontology · 2016Article
- Involvement of ALAD-20S Proteasome Complexes in Ubiquitination and Acetylation of Proteasomal α2 Subunits.Journal of cellular biochemistry · 2016Article
- A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs.Biology direct · 2014Article
- Case-only gene-environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer.The Prostate · 2014Article
- Crude and purified proteasome activity assays are affected by type of microplate.Analytical biochemistry · 2014Article
- Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human.Molecular & cellular proteomics : MCP · 2013Article
- From bortezomib to other inhibitors of the proteasome and beyond.Current pharmaceutical design · 2013Review
- Association of metals and proteasome activity in erythrocytes of prostate cancer patients and controls.Biological trace element research · 2012Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The proteasome interacts with a large number of proteins which regulate specific cellular functions. The focus of this study is to examine the proteasome interaction with Delta-aminolevulinate dehydratase (ALAD). ALAD is involved in the heme biosynthesis pathway and was co-isolated, with the 20S proteasome using several chromatographic purification steps. The MALDI-TOF mass spectrometry analysis identified this proteasome co-isolated protein as ALAD. When the proteasome was isolated using density-gradient centrifugation, ALAD was also found in the 26S proteasome fractions. It co-isolated with the 20S more than with the 26S proteasome. Furthermore, immunoprecipitated ALAD stained positive with antibodies to proteasome subunits. These results indicate that ALAD might interact with the proteasome. It is possible that ALAD is involved in modulating proteasome activity. When purified proteasomes were incubated with ALAD it was found that ALAD changes proteasome activity in a dose dependent manner. This indicates that ALAD may play a significant role in regulating proteasome activity. The data supports the hypothesis that ALAD, an important enzyme for heme synthesis, is also important as a proteasome interacting protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.