Evidence map›Paper›PMID 21640700›Full record

ReviewArchives of biochemistry and biophysics2011

Cellular magnesium homeostasis.

Andrea M P Romani

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 262 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

262 citing papers in PubMed, 1 synthesis or guideline pooled it, 520 citations in OpenAlex.

  1. Pooled it
  2. Role of an Angiotensin II Type-1 Receptor (ATBiological trace element research · 2026
    Article
  3. Host-derived stimuli alter intracellular calcium levels inApplied and environmental microbiology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Biophysical characterization ofSensors & diagnostics · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Quantifying MgbioRxiv : the preprint server for biology · 2026
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

202 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Andrea M P RomaniDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA. amr5@po.cwru.edu
Case Western Reserve University · US

Funding

Mg2+ homeostasis in liver cells treated with EtOHR01AA011593 · NIAAA · CASE WESTERN RESERVE UNIVERSITY · PI ROMANI, ANDREA M · 2000 to 2009
$1.5M
NIAAA NIH HHS R01 AA011593
6 · The paper itself

Abstract

Magnesium, the second most abundant cellular cation after potassium, is essential to regulate numerous cellular functions and enzymes, including ion channels, metabolic cycles, and signaling pathways, as attested by more than 1000 entries in the literature. Despite significant recent progress, however, our understanding of how cells regulate Mg(2+) homeostasis and transport still remains incomplete. For example, the occurrence of major fluxes of Mg(2+) in either direction across the plasma membrane of mammalian cells following metabolic or hormonal stimuli has been extensively documented. Yet, the mechanisms ultimately responsible for magnesium extrusion across the cell membrane have not been cloned. Even less is known about the regulation in cellular organelles. The present review is aimed at providing the reader with a comprehensive and up-to-date understanding of the mechanisms enacted by eukaryotic cells to regulate cellular Mg(2+) homeostasis and how these mechanisms are altered under specific pathological conditions.

Indexed as

Cell Membrane PermeabilityAnimalsCell Physiological PhenomenaHomeostasisHumansIon ChannelsMagnesiumIon ChannelsMagnesium

Identifiers

PMID21640700
PMCPMC3133480
OpenAlexW2021088564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.