Evidence map›Paper›PMID 21640657›Full record

ArticleJournal of the American Medical Directors Association2011

Sarcopenia with limited mobility: an international consensus.

John E Morley, Angela Marie Abbatecola, Josep M Argiles, Vickie Baracos, Juergen Bauer, Shalender Bhasin, Tommy Cederholm, Andrew J Stewart Coats, Steven R Cummings, William J Evans and 22 more

Registry-linked trialOpen access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Medical Directors Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07356440 (Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects), which is not on this map. Cited by 462 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
462citing papers in PubMed, 20 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07356440 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects

TypeinterventionalSponsorUniversity of UdineRan2025 to 2026Enrolled74ConditionsSarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome AnalysisArmsVitamin D3 supplement, Protein-enriched biscuits, Control biscuit, Placebo oil
3 · Its place in the literature

Who cites it

462 citing papers in PubMed, 20 syntheses or guidelines pooled it, 1,116 citations in OpenAlex.

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  20. Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAXJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Pooled it

402 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 9 countries.

John E MorleyDivision of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St. Louis, MO 63104, USA. morley@slu.edu
Angela Marie Abbatecola
Josep M Argiles
Vickie Baracos
Juergen Bauer
Shalender Bhasin
Tommy Cederholm
Andrew J Stewart Coats
Steven R Cummings
William J Evans
Kenneth Fearon
Luigi Ferrucci
Roger A Fielding
Jack M Guralnik
Tamara B Harris
Akio Inui
Kamyar Kalantar-Zadeh
Bridget-Anne Kirwan
Giovanni Mantovani
Maurizio Muscaritoli
Anne B Newman
Filippo Rossi-Fanelli
Giuseppe M C Rosano
Ronenn Roubenoff
Morris Schambelan
Gerald H Sokol
Thomas W Storer
Bruno Vellas
Stephan von Haehling
Shing-Shing Yeh
Stefan D Anker
Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop
Boston University · USCharité - Universitätsmedizin Berlin · DENational Institutes of Health · USSapienza University of Rome · ITUniversity of California, San Francisco · USDuke University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Nazionale di Riposo e Cura per Anziani · ITKagoshima University · JPMoffitt Cancer Center · USNational Institute on Aging · USNorthport VA Medical Center · USSaint Louis University · USTufts Medical Center · USTufts University · USUniversitat de Barcelona · ESUniversité de Toulouse · FRUniversity of Alberta · CAUniversity of Cagliari · IT

Funding

The Baltimore Longitudinal Study Of AgingZIAAG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI SIMONSICK, ELEANOR MARIE · 2009 to 2025
$116.9M
THE BALTIMORE LONGITUDINAL STUDY OF HUMAN AGINGZ01AG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 1985 to 2008
$11.4M
Intramural NIH HHS Z01 AG000015
6 · The paper itself

Abstract

A consensus conference convened by the Society of Sarcopenia, Cachexia and Wasting Disorders has concluded that "Sarcopenia, ie, reduced muscle mass, with limited mobility" should be considered an important clinical entity and that most older persons should be screened for this condition. "Sarcopenia with limited mobility" is defined as a person with muscle loss whose walking speed is equal to or less than 1 m/s or who walks less than 400 m during a 6-minute walk, and who has a lean appendicular mass corrected for height squared of 2 standard deviations or more below the mean of healthy persons between 20 and 30 years of age of the same ethnic group. The limitation in mobility should not clearly be a result of otherwise defined specific diseases of muscle, peripheral vascular disease with intermittent claudication, central and peripheral nervous system disorders, or cachexia. Clinically significant interventions are defined as an increase in the 6-minute walk of at least 50 meters or an increase of walking speed of at least 0.1 m/s.

Indexed as

InternationalityMobility LimitationAgedFemaleHumansMaleMiddle AgedMuscle, SkeletalSarcopenia

Identifiers

PMID21640657
PMCPMC5100674
OpenAlexW2048798480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.