Evidence map›Paper›PMID 21640360›Full record

Trial reportMetabolism: clinical and experimental2011

Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome.

M Luisa Vargas, Rogelio U Almario, Wendy Buchan, Kyoungmi Kim, Sidika E Karakas

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Metabolism: clinical and experimental, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03122912 (Explore Effects of Dietary Fish Oil in Human Skin), which is not on this map. Cited by 29 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 9 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03122912 phase1terminatednot on this mapstarted 2018, after this paper: background citation

Explore Effects of Dietary Fish Oil in Human Skin

TypeinterventionalSponsorUniversity of MichiganRan2018 to 2021Enrolled17ConditionsAging ProblemsArmsFish Oil, Soybean Oil
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 9 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. The Plasma Glycome Differences Between Women with PCOS and Healthy Controls.International journal of molecular sciences · 2026
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M Luisa VargasDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis, Davis, CA 95817, USA.
Rogelio U Almario
Wendy Buchan
Kyoungmi Kim
Sidika E Karakas
University of California, Davis · USCalifornia State University, Sacramento · US

Funding

UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOSR21AT003401 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KARAKAS, SIDIKA E · 2007 to 2009
$600k
NCCIH NIH HHS AT003401NCCIH NIH HHS R21 AT003401NCRR NIH HHS RR 024146NCRR NIH HHS UL1 RR024146
6 · The paper itself

Abstract

The objective of the study was to compare the effects of essential vs long-chain omega (n)-3 polyunsaturated fatty acids (PUFAs) in polycystic ovary syndrome. In this 6-week, prospective, double-blinded, placebo (soybean oil)-controlled study, 51 completers received 3.5 g n-3 PUFA per day (essential PUFA from flaxseed oil or long-chain PUFA from fish oil). Anthropometric variables, cardiovascular risk factors, and androgens were measured; oral glucose tolerance test (OGTT) and frequently sampled intravenous GTT (IVGTT) were conducted at baseline and 6 weeks. Between-group comparisons showed significant differences in serum triglyceride response (P = .0368), whereas the changes in disposition index also tended to differ (P = .0621). When within-group changes (after vs before intervention) were considered, fish oil and flaxseed oil lowered serum triglyceride (P = .0154 and P = .0176, respectively). Fish oil increased glucose at 120 minutes of OGTT (P = .0355), decreased the Matsuda index (P = .0378), and tended to decrease acute insulin response during IVGTT (P = .0871). Soybean oil increased glucose at 30 (P = .0030) and 60 minutes (P = .0121) and AUC for glucose (P = .0122) during OGTT, tended to decrease acute insulin response during IVGTT (P = .0848), reduced testosterone (P = .0216), and tended to reduce sex hormone-binding globulin (P = .0858). Fasting glucose, insulin, adiponectin, leptin, or high-sensitivity C-reactive protein did not change with any intervention. Long-chain vs essential n-3 PUFA-rich oils have distinct metabolic and endocrine effects in polycystic ovary syndrome; and therefore, they should not be used interchangeably.

Indexed as

AdultBiomarkersBlood GlucoseC-Reactive ProteinDietary SupplementsDocosahexaenoic AcidsDouble-Blind MethodDrug Administration ScheduleEicosapentaenoic AcidFatty Acids, EssentialFatty Acids, Omega-3FemaleFish OilsGlucose Tolerance TestHumansHyperinsulinismBiomarkersBlood GlucoseC-Reactive ProteinDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, EssentialFatty Acids, Omega-3Fish OilsInsulinLinseed OilSex Hormone-Binding GlobulinSoybean OilTestosteroneTriglycerides

Identifiers

PMID21640360
PMCPMC3210884
OpenAlexW2064000729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.