ArticleThe Journal of cell biology1990
The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
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- Jamming transitions in cancer.Journal of physics D: Applied physics · 2017Article
- Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy.Oncogenesis · 2017Article
- Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.NPJ breast cancer · 2017Article
- Breast Cancer beyond the Age of Mutation.Gerontology · 2016Article
- Feather on the Cap of Medicine.The Journal of investigative dermatology · 2015Article
- Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype.Wiley interdisciplinary reviews. Membrane transport and signaling · 2014Article
- Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?Cancer metastasis reviews · 2013Review
- Platinum-sensitive recurrence in ovarian cancer: the role of tumor microenvironment.Frontiers in oncology · 2013Review
- Article
- Stromal biomarkers in breast cancer development and progression.Clinical & experimental metastasis · 2012Review
- The complexities of TGF-β action during mammary and squamous cell carcinogenesis.Current pharmaceutical biotechnology · 2011Review
- In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages.Integrative biology : quantitative biosciences from nano to macro · 2011Article
- Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression.Nature medicine · 2011Review
- The mammary gland microenvironment directs progenitor cell fate in vivo.International journal of cell biology · 2011Article
- Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.The Journal of biological chemistry · 2009Article
- Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation.Cancer research · 2008Article
- Architecture Is the Message: The role of extracellular matrix and 3-D structure in tissue-specific gene expression and breast cancer.The Pezcoller Foundation journal : news from the Pezcoller Foundation world · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate that the behavior of cells expressing v-src, a tyrosine kinase oncogene, differs profoundly between the embryonic and culture environments. V-src was introduced into avian embryo cells both in culture and in stage-24 embryo limbs, using replication-defective retroviral vectors. These vectors were used as single-hit, cellular markers to determine the environmental influences imposed by normal cells and tissues on clonal cell growth. The marker gene lacZ was coexpressed with v-src in order to locate the descendent cells. In culture, v-src induced rapid morphological transformation and anchorage-independent growth of embryo fibroblasts; the vectors were also tumorigenic in hatchling chickens. In contrast, most of the cell clones expressing v-src in the embryo grew normally without neoplasia. Expression of v-src vectors could be found in a wide range of cell types, demonstrating not only that neoplastic transformation is attenuated in ovo, but also that differentiation commitment in many lineages can be maintained concurrently with oncogene expression. Significantly, the embryonic control of cell growth could be perturbed by v-src under certain conditions. Rare, marked clones showed hyperplasia or dysplasia, and the primitive endothelium could succumb to rapid neoplasia; thus, these embryonic tissues are not inherently deficient in transformation factors. We propose that the environmental conditions imposed on cells in ovo are critical for the attenuation of neoplasia, while cultured cells lose this requisite environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.