ReviewJournal of chemical neuroanatomy2011
Development by environment interactions controlling tryptophan hydroxylase expression.
Review in Journal of chemical neuroanatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Serotonergic System Dysregulation in Alzheimer's Disease.ACS chemical neuroscience · 2026Review
- Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer's disease.Molecular psychiatry · 2025Article
- Association of Non-Suicidal Self-Injury with Tryptophan Hydroxylase 2 Gene Polymorphism and Negative Life Events Among Adolescents with Depression in Northern China.Psychology research and behavior management · 2024Article
- Article
- Effect of childhood general traumas on suicide attempt depends on TPH2 and ADARB1 variants in psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Cell-Autonomous Gβ Signaling Defines Neuron-Specific Steady State Serotonin Synthesis in Caenorhabditis elegans.PLoS genetics · 2015Article
- Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system.Behavioural brain research · 2014Article
- Fibroblast growth factor 8 deficiency compromises the functional response of the serotonergic system to stress.PloS one · 2014Article
- Prior cold water swim stress alters immobility in the forced swim test and associated activation of serotonergic neurons in the rat dorsal raphe nucleus.Neuroscience · 2013Article
- Development × environment interactions control tph2 mRNA expression.Neuroscience · 2013Article
- Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders.Cellular and molecular neurobiology · 2012Review
- Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression.Psychoneuroendocrinology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different genes, tph1 and tph2, have been identified. The tph1 isoform is expressed in peripheral tissues, whereas tph2 is brain and neuron-specific. Recent studies suggest that tph2 expression and brain serotonin turnover are upregulated in depressed suicide patients, and drug-free depressed patients, respectively. Increased tph2 expression could result from genetic influences, early life developmental influences, adverse experience during adulthood, or interactions among these factors. Studies in rodents support the hypothesis that interactions between early life developmental influences and adverse experience during adulthood play an important role in determining tph2 expression. In this review, we highlight the evidence for the effects of adverse early life experience and stressful experience during adulthood on both tph1 and tph2 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.