ReviewJournal of chemical neuroanatomy2011
The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis.
Review in Journal of chemical neuroanatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Sudden Unexpected Death in Epilepsy: A Narrative Review of Mechanism, Risks, and Prevention.Journal of clinical medicine · 2025Review
- Platelet Pathophysiology: Unexpected New Research Directions.Seminars in thrombosis and hemostasis · 2024Article
- Perinatal asphyxia and hypothermic treatment from the endocrine perspective.Frontiers in endocrinology · 2023Review
- Neuroanatomy of the Will.NeuroSci · 2022Article
- Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets.PloS one · 2021Article
- Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study.Frontiers in neurology · 2021Article
- The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome.Journal of neuropathology and experimental neurology · 2019Review
- Variability of the medullary arcuate nucleus in humans.Brain and behavior · 2018Article
- The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy.Brain : a journal of neurology · 2018Article
- Some Autonomic Deficits of Acute or Chronic Cervical Spinal Contusion Reversed by Interim Brainstem Stimulation.Journal of neurotrauma · 2018Article
- Serotonin neuron development: shaping molecular and structural identities.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Article
- Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage Study.Journal of neuropathology and experimental neurology · 2016Article
- Key Brainstem Structures Activated during Hypoxic Exposure in One-day-old Mice Highlight Characteristics for Modeling Breathing Network in Premature Infants.Frontiers in physiology · 2016Article
- Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.Psychopharmacology · 2014Article
- Serotonin metabolites in the cerebrospinal fluid in sudden infant death syndrome.Journal of neuropathology and experimental neurology · 2014Article
- Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infants.Pediatrics · 2013Article
- Medullary serotonin neurons are CO2 sensitive in situ.Journal of neurophysiology · 2013Article
- The physiological determinants of sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
- Serotonin gene variants are unlikely to play a significant role in the pathogenesis of the sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The caudal serotonergic (5-HT) system is a critical component of a medullary "homeostatic network" that regulates protective responses to metabolic stressors such as hypoxia, hypercapnia, and hyperthermia. We define anatomically the caudal 5-HT system in the human medulla as 5-HT neuronal cell bodies located in the raphé (raphé obscurus, raphé magnus, and raphé pallidus), extra-raphé (gigantocellularis, paragigantocellularis lateralis, intermediate reticular zone, lateral reticular nucleus, and nucleus subtrigeminalis), and ventral surface (arcuate nucleus). These 5-HT neurons are adjacent to all of the respiratory- and autonomic-related nuclei in the medulla where they are positioned to modulate directly the responses of these effector nuclei. In the following review, we highlight the topography and development of the caudal 5-HT system in the human fetus and infant, and its inter-relationships with nicotinic, GABAergic, and cytokine receptors. We also summarize pediatric disorders in early life which we term "developmental serotonopathies" of the caudal (as well as rostral) 5-HT domain and which are associated with homeostatic imbalances. The delineation of the development and organization of the human caudal 5-HT system provides the critical foundation for the neuropathologic elucidation of its disorders directly in the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.