Evidence map›Paper›PMID 21640179›Full record

ArticleHearing research2011

Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel.

Debin Lei, Xia Gao, Philip Perez, Kevin K Ohlemiller, Chien-Chang Chen, Kevin P Campbell, Aizhen Yang Hood, Jianxin Bao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. CaInternational journal of molecular sciences · 2022
    Review
  6. Association between CaExperimental gerontology · 2021
    Article
  7. Review
  8. Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.Journal of the Association for Research in Otolaryngology : JARO · 2018
    Article
  9. Article
  10. Review
  11. T-type calcium channel blockers as neuroprotective agents.Pflugers Archiv : European journal of physiology · 2014
    Review
  12. Article
  13. Review
  14. Intracerebral neural stem cell transplantation improved the auditory of mice with presbycusis.International journal of clinical and experimental pathology · 2013
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Debin LeiDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xia Gao
Philip Perez
Kevin K Ohlemiller
Chien-Chang Chen
Kevin P Campbell
Aizhen Yang Hood
Jianxin Bao
Washington University in St. Louis · USHoward Hughes Medical Institute · USNanjing Drum Tower Hospital · CNUniversity of Iowa · US

Funding

Washington University Center for Translational NeuroscienceP30NS057105 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2006 to 2011
$8.7M
Sensory Function CoreP30DC004665 · NIDCD · WASHINGTON UNIVERSITY · PI CHOLE, RICHARD ARTHUR · 2001 to 2015
$8.0M
DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSSR33DC010489 · NIDCD · WASHINGTON UNIVERSITY · PI BAO, JIANXIN · 2011 to 2013
$1.7M
Roles of Neurequlin-1 in Age Related Neuronal ChangesR01AG024250 · NIA · WASHINGTON UNIVERSITY · PI BAO, JIANXIN · 2004 to 2009
$1.7M
DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSSR21DC010489 · NIDCD · WASHINGTON UNIVERSITY · PI BAO, JIANXIN · 2009 to 2010
$416k
NIA NIH HHS R01 AG024250NIA NIH HHS R01AG024250NIDCD NIH HHS P30 DC004665NIDCD NIH HHS P30DC004665NIDCD NIH HHS R21 DC010489NIDCD NIH HHS R21DC010489NIDCD NIH HHS R33 DC010489NINDS NIH HHS P30 NS057105NINDS NIH HHS P30NS057105
6 · The paper itself

Abstract

Loss of spiral ganglion neurons is a major cause of age-related hearing loss (presbycusis). Despite being the third most prevalent condition afflicting elderly persons, there are no known medications to prevent presbycusis. Because calcium signaling has long been implicated in age-related neuronal death, we investigated T-type calcium channels. This family is comprised of three members (Ca(v)3.1, Ca(v)3.2, and Ca(v)3.3), based on their respective main pore-forming alpha subunits: α1G, α1H, and α1I. In the present study, we report a significant delay of age-related loss of cochlear function and preservation of spiral ganglion neurons in α1H null and heterozygous mice, clearly demonstrating an important role for Ca(v)3.2 in age-related neuronal loss. Furthermore, we show that anticonvulsant drugs from a family of T-type calcium channel blockers can significantly preserve spiral ganglion neurons during aging. To our knowledge, this is the first report of drugs capable of diminishing age-related loss of spiral ganglion neurons.

Indexed as

AgingAnimalsAnticonvulsantsBase SequenceCalcium Channel BlockersCalcium Channels, T-TypeEvoked Potentials, Auditory, Brain StemHair Cells, Auditory, InnerHair Cells, Auditory, OuterMiceMice, CongenicMice, KnockoutNeuronsPresbycusisRNASpiral GanglionAnticonvulsantsCacna1g protein, mouseCacna1h protein, mouseCacna1i protein, mouseCalcium Channel BlockersCalcium Channels, T-TypeRNA

Identifiers

PMID21640179
PMCPMC3152691
OpenAlexW2047894292

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.