ArticleBiochimica et biophysica acta2011
Brief treatment with heparin-binding EGF-like growth factor, but not with EGF, is sufficient to accelerate epithelial wound healing.
Article in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Elucidating the mechanism of corneal epithelial cell repair: unraveling the impact of growth factors.Frontiers in medicine · 2024Review
- Article
- Review
- Extending the use of biologics to mucous membranes by attachment of a binding domain.Communications biology · 2023Article
- Wound healing of the corneal epithelium: a review.Asian biomedicine : research, reviews and news · 2021Review
- Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells.Scientific reports · 2019Article
- CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.International journal of biological sciences · 2019Article
- Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Critical Mediator of Tissue Repair and Regeneration.The American journal of pathology · 2018Review
- Review: Multimodal bioactive material approaches for wound healing.APL bioengineering · 2018Review
- Progress in corneal wound healing.Progress in retinal and eye research · 2015Review
- iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function.Human molecular genetics · 2014Article
- Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo.Oncogene · 2014Article
- Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCδ).Investigative ophthalmology & visual science · 2014Article
- The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.Investigative ophthalmology & visual science · 2014Article
- The wound healing, chronic fibrosis, and cancer progression triad.Physiological genomics · 2014Review
- The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL.Tissue engineering. Part A · 2013Article
- Essential roles of heparin-binding epidermal growth factor-like growth factor in the brain.CNS neuroscience & therapeutics · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeparin-binding EGF-like growth factor (HB-EGF) contains, in contrast to EGF, a domain that binds to negatively charged glycans on cell surfaces and in extracellular matrix. We speculated that a short exposure to HB-EGF induces prolonged biological effects such as healing of wounds after immobilization in tissues.
methodsEpithelial cell sheets in tissue and corneas in organ culture were treated briefly with HB-EGF or EGF and binding of the growth factors, time course of activation of the EGF receptor, and healing of wounds were compared.
resultsTreating human corneal epithelial cells for 2 min with HB-EGF resulted in 8h of detectable activation of the EGF receptor, but activation was much shorter after EGF treatment. A brief treatment with HB-EGF, but not with EGF, induced significant acceleration of healing in wounds in epithelial sheets in tissue and organ culture. Bound HB-EGF was detectable up to 16 h after brief treatments. Neutralizing antibodies added after HB-EGF treatment blocked acceleration of healing, demonstrating the role of bound HB-EGF in accelerating healing.
conclusionsA brief exposure to HB-EGF, but not to EGF, is sufficient to induce prolonged activation of the EGF receptor and to enhance healing. GENERAL SIGNIFICANCE: Bound HB-EGF can serve as a pool that induces prolonged activation of the EGF receptor. EGF has been used experimentally to treat poorly healing wounds, but the frequent applications that are necessary have hampered its use clinically. The findings imply that HB-EGF may be a useful long-acting alternative to EGF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.