ArticleBMC genetics2011
Interpopulation hybridization results in widespread viability selection across the genome in Tigriopus californicus.
Article in BMC genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Hybridization and Immunology in Animals: A Review.Ecology and evolution · 2026Review
- Genomics Reveal Admixture and Unexpected Patterns of Diversity in a Parapatric Pair of Butterflies.Genes · 2021Article
- FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung CancerFrontiers in pharmacology · 2021Article
- Strong selective effects of mitochondrial DNA on the nuclear genome.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A genetic linkage map for the salmon louse (Lepeophtheirus salmonis): evidence for high male:female and inter-familial recombination rate differences.Molecular genetics and genomics : MGG · 2019Article
- Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer.Molecules (Basel, Switzerland) · 2019Article
- RAD-seq reveals genetic structure of the FBMC plant biology · 2018Article
- Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions.PLoS genetics · 2017Article
- Chromosome-Wide Impacts on the Expression of Incompatibilities in Hybrids of Tigriopus californicus.G3 (Bethesda, Md.) · 2016Article
- Identification and Characterization of Segregation Distortion Loci on Cotton Chromosome 18.Frontiers in plant science · 2016Article
- Genetic architecture and genomic patterns of gene flow between hybridizing species of Picea.Heredity · 2015Article
- Pacific and Atlantic Lepeophtheirus salmonis (Krøyer, 1838) are allopatric subspecies: Lepeophtheirus salmonis salmonis and L. salmonis oncorhynchi subspecies novo.BMC genetics · 2014Article
- No boundaries: genomes, organisms, and ecological interactions responsible for divergence and reproductive isolation.The Journal of heredity · 2014Review
- Article
- Article
- High cryptic diversity across the global range of the migratory planktonic copepods Pleuromamma piseki and P. gracilis.PloS one · 2013Article
- A gene-based SNP resource and linkage map for the copepod Tigriopus californicus.BMC genomics · 2011Article
- Observing copepods through a genomic lens.Frontiers in zoology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic interactions within hybrids influence their overall fitness. Understanding the details of these interactions can improve our understanding of speciation. One experimental approach is to investigate deviations from Mendelian expectations (segregation distortion) in the inheritance of mapped genetic markers. In this study, we used the copepod Tigriopus californicus, a species which exhibits high genetic divergence between populations and a general pattern of reduced fitness in F2 interpopulation hybrids. Previous studies have implicated both nuclear-cytoplasmic and nuclear-nuclear interactions in causing this fitness reduction. We identified and mapped population-diagnostic single nucleotide polymorphisms (SNPs) and used these to examine segregation distortion across the genome within F2 hybrids.
resultsWe generated a linkage map which included 45 newly elucidated SNPs and 8 population-diagnostic microsatellites used in previous studies. The map, the first available for the Copepoda, was estimated to cover 75% of the genome and included markers on all 12 T. californicus chromosomes. We observed little segregation distortion in newly hatched F2 hybrid larvae (fewer than 10% of markers at p < 0.05), but strikingly higher distortion in F2 hybrid adult males (45% of markers at p < 0.05). Hence, segregation distortion was primarily caused by selection against particular genetic combinations which acted between hatching and maturity. Distorted markers were not distributed randomly across the genome but clustered on particular chromosomes. In contrast to other studies in this species we found little evidence for cytonuclear coadaptation. Instead, different linkage groups exhibited markedly different patterns of distortion, which appear to have been influenced by nuclear-nuclear epistatic interactions and may also reflect genetic load carried within the parental lines.
conclusionAdult male F2 hybrids between two populations of T. californius exhibit dramatic segregation distortion across the genome. Distorted loci are clustered within specific linkage groups, and the direction of distortion differs between chromosomes. This segregation distortion is due to selection acting between hatching and adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.