Trial reportAnnals of medicine2012
Effect of aerobic training on hot flushes and quality of life--a randomized controlled trial.
Trial report in Annals of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Optimal doses of different exercise types for improving depressive symptoms in climacteric women: a systematic review and network meta-analysis.Frontiers in psychology · 2026Pooled it
- Effects of different physical activity interventions on depressive symptoms in menopausal women: a systematic review and network meta-analysis.BMC public health · 2025Pooled it
- Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause: a comprehensive systematic review and meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2020Pooled it
- Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review.BJOG : an international journal of obstetrics and gynaecology · 2020Pooled it
- Guideline
- Exercise for vasomotor menopausal symptoms.The Cochrane database of systematic reviews · 2014Pooled it
- Effectiveness of face-to-face and web-based exercise programs on health outcomes in early postmenopausal women: a randomized trial.BMC women's health · 2026Trial
- The effect of motivational interviewing on healthy lifestyle behaviors and quality of life in on menopausal women: a pilot randomized controlled trial.BMC women's health · 2025Trial
- Women's views about physical activity as a treatment for vasomotor menopausal symptoms: a qualitative study.BMC women's health · 2020Trial
- Effects of stretching on menopausal and depressive symptoms in middle-aged women: a randomized controlled trial.Menopause (New York, N.Y.) · 2016Trial
- Trial
- Cost-effectiveness of physical activity among women with menopause symptoms: findings from a randomised controlled trial.PloS one · 2015Trial
- Efficacy of exercise for menopausal symptoms: a randomized controlled trial.Menopause (New York, N.Y.) · 2014Trial
- Management of menopausal hot flushes. Recommendations from the Spanish Menopause Society.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Evidence and consensus-based clinical practice guidelines for management of overweight and obesity in midlife women: An AIIMS-DST initiative.Journal of family medicine and primary care · 2022Review
- [Preventive activities in women. PAPPS update 2022].Atencion primaria · 2022Article
- Nonpharmacological therapies for the management of menopausal vasomotor symptoms in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Review
- [Preventive activities in women's care].Atencion primaria · 2020Article
- Effect of aerobic exercises versus laser acupuncture in treatment of postmenopausal hot flushes: a randomized controlled trial.Journal of physical therapy science · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveTo estimate whether aerobic training has an effect on frequency of hot flushes or quality of life.
designA randomized controlled trial. PARTICIPANTS AND
settingSymptomatic, sedentary women (n = 176), 43-63 years, no current use of hormone therapy.
interventionUnsupervised aerobic training for 50 minutes four times per week during 6 months. OUTCOMES: Hot flushes as measured with Women's Health Questionnaire (WHQ) and Health-Related Quality of Life (HRQoL, SF-36), daily reported hot flushes on phone-based diary, cardiorespiratory fitness (CRF), and body composition.
resultsIntervention group had larger decrease in the frequency of night-time hot flushes based on phone diary (P for month × group = 0.012), but not on WHQ scale. Intervention group had less depressed mood (P = 0.01) than control women according to change in WHQ score. Changes in WHQ score in depressed mood (P = 0.03) and menstrual symptoms (P = 0.01) in the intervention group were significantly dependent on frequency of training sessions. HRQoL was improved among the intervention group women in physical functioning (P = 0.049) and physical role limitation (P = 0.017). CRF improved (P = 0.008), and lean muscle mass increased (P = 0.046) significantly in the intervention group as compared to controls.
conclusionsAerobic training may decrease the frequency of hot flushes and improve quality of life among slightly overweight women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.