ArticleDevelopmental psychology2011
Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence.
Article in Developmental psychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Socioeconomic status and inflammation: a meta-analysis.Molecular psychiatry · 2020Pooled it
- Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.Biological psychiatry · 2016Pooled it
- Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia.BMC medicine · 2023Article
- The Long Arm of childhood hypothesis and systematic low-grade inflammation: Evidence from parental education of older European adults.SSM - population health · 2023Article
- Increased Frequencies of the ‒174G and ‒572CMolecular biology · 2023Article
- Insomnia symptoms are associated with an increased risk of type 2 diabetes mellitus among adults aged 50 and older.Sleep & breathing = Schlaf & Atmung · 2022Article
- Review
- Resilience to health challenges is related to different ways of thinking: mediators of physical and emotional quality of life in a heterogeneous rare-disease cohort.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Associations Among Child Abuse, Depression, and Interleukin-6 in Pregnant Adolescents: Paradoxical Findings.Psychosomatic medicine · 2016Article
- Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth.Brain, behavior, and immunity · 2015Article
- Socioeconomic status, daily affective and social experiences, and inflammation during adolescence.Psychosomatic medicine · 2015Article
- Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers.Development and psychopathology · 2014Article
- IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort.BMC cancer · 2014Article
- Inverse correlation of serum inflammatory markers with metabolic parameters in healthy, Black and White prepubertal youth.International journal of obesity (2005) · 2014Article
- Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study.Psychological medicine · 2013Article
- Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
- Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- When grief makes you sick: bereavement induced systemic inflammation is a question of genotype.Brain, behavior, and immunity · 2012Article
- The social determinants of health: it's time to consider the causes of the causes.Public health reports (Washington, D.C. : 1974)Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The authors tested the evolutionary genetic hypothesis that the functional form of an asymmetrically risky Gene × Environment interaction will differ as a function of age-related antagonistic pleiotropy (i.e., show opposite effects in young vs. old individuals). Previous studies have identified a polymorphism in the human IL6 promoter (rs1800795; IL6-74 G/C) that interacts with adverse socioenvironmental conditions to promote chronic inflammation in older adults (elevated C-reactive protein). This study identifies a protective effect of the same polymorphism in 17- to 19-year-old adolescents confronting socioeconomic adversity. Over 60% of the environmental risk contribution to the IL6 × Socioeconomic Status interaction could be accounted for by interpersonal stress and adult role burden. Thus, the IL6-174G allele does not represent an undifferentiated risk factor but instead sensitizes inflammatory biology to socioenvironmental conditions, conferring either genetic vulnerability or resilience depending on the developmental "somatic environment" that interacts with social conditions to influence gene expression.
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Registered trials
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