ArticleMolecules and cells2011
Pathway-specific alteration of synaptic plasticity in Tg2576 mice.
Article in Molecules and cells, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Decoding the mechanisms of amyloid-β in synaptic toxicity.Journal of Alzheimer's disease : JAD · 2026Review
- Navigating Alzheimer's Disease Mouse Models: Age-Related Pathology and Cognitive Deficits.Biomolecules · 2024Review
- Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia.Metabolic brain disease · 2024Article
- Honey and Alzheimer's Disease-Current Understanding and Future Prospects.Antioxidants (Basel, Switzerland) · 2023Review
- Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models.Brain communications · 2020Article
- TMagnetic resonance imaging · 2018Article
- Astrocytes and synaptic plasticity in health and disease.Experimental brain research · 2017Review
- Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease.Nature communications · 2017Article
- Neuritin can normalize neural deficits of Alzheimer's disease.Cell death & disease · 2014Article
- c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.Cell death & disease · 2014Article
- Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery.World journal of stem cells · 2013Article
- In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes.Journal of the American College of Cardiology · 2012Article
- Spines, plasticity, and cognition in Alzheimer's model mice.Neural plasticity · 2012Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various animal models of Alzheimer disease (AD) are characterized by deficits in spatial memory that are causally related to altered synaptic function and impairment of long-term potentiation (LTP) in the hippocampus. In Tg2576 AD mice, we compared LTP in 2 major hippocampal pathways, Schaffer collateral (SC) and mossy fiber (MF) pathways. Whereas LTP was completely abolished in the SC pathway of Tg2576 mice, we found no decrease in LTP induced by stimulation of the MF pathway. In fact, we found that in the MF pathway, LTP was slightly, but significantly, enhanced compared with that in the MF pathway of WT littermates. This pathway-specific impairment of LTP is not attributable to alterations in transmitter release, as indicated by an unaltered paired-pulse ratio. These results suggest that the spatial memory deficits normally seen in AD models arise primarily from LTP impairment at the SC pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.