ArticleClinical orthopaedics and related research2011
Amphotericin B delivery from bone cement increases with porosity but strength decreases.
Article in Clinical orthopaedics and related research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The heavy burden and treatment challenges of fungal periprosthetic joint infection: a systematic review of 489 joints.BMC musculoskeletal disorders · 2024Pooled it
- Candida periprosthetic infection of the knee: a systematic review of surgical treatments and clinical outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Pooled it
- Candida periprosthetic infection of the hip: a systematic review of surgical treatments and clinical outcomes.International orthopaedics · 2020Pooled it
- Non-intravenous Amphotericin B: A Review of Localized Administration Routes.Infectious diseases and therapy · 2026Review
- Antimicrobial 3D printed implants for periprosthetic joint infections.Drug delivery and translational research · 2026Article
- Fungal Prosthetic Joint Infection byAntibiotics (Basel, Switzerland) · 2025Article
- Evaluation and testing of polymethylmetacrylic (PMMA) bone cements with admixed Amphotericin B.Journal of orthopaedic surgery and research · 2025Article
- Clinical practice guidelines for antimicrobial-loaded cements and beads in orthopedic trauma and arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Review
- Voriconazole Admixed with PMMA-Impact on Mechanical Properties and Efficacy.Antibiotics (Basel, Switzerland) · 2023Article
- Epidemiology of Fungal Periprosthetic Joint Infection: A Systematic Review of the Literature.Microorganisms · 2022Review
- Osteoarticular Mycoses.Clinical microbiology reviews · 2022Review
- Antifungal-Loaded Acrylic Bone Cement in the Treatment of Periprosthetic Hip and Knee Joint Infections: A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement.Journal of fungi (Basel, Switzerland) · 2022Review
- Metagenomic next-generation sequencing assists the diagnosis treatment of fungal osteoarticular infections.Frontiers in cellular and infection microbiology · 2022Article
- Three-stage revision arthroplasty for the treatment of fungal periprosthetic joint infection: outcome analysis of a novel treatment algorithm : a prospective study.Bone & joint open · 2021Article
- Candida Periprosthetic Joint Infection: Is It Curable?Antibiotics (Basel, Switzerland) · 2021Article
- Resorbable Beads Provide Extended Release of Antifungal Medication: In Vitro and In Vivo Analyses.Pharmaceutics · 2019Article
- Oritavancin polymethylmethacrylate (PMMA)-compressive strength testing and in vitro elution.Journal of orthopaedic surgery and research · 2019Article
- Article
- Risk factors and the clinical and surgical features of fungal prosthetic joint infections: A retrospective analysis of eight cases.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmphotericin B is a highly hydrophobic antifungal used for orthopaedic infections. There is disagreement about whether amphotericin B is released when it is loaded in polymethylmethacrylate (PMMA). It is unknown how much a poragen will increase amphotericin B release or decrease the compressive strength of the PMMA. QUESTIONS/PURPOSES: We therefore measured amphotericin B release and the compressive strength of amphotericin B loaded bone cement with and without adding high-dose poragen.
methodsAntifungal-loaded bone cement was formulated with Simplex P cement and 200 mg amphotericin B with and without 10 g cefazolin (poragen) per batch. Twenty standardized test cylinders were eluted in deionized water for each formulation. Cumulative amphotericin B mass and compressive strength were measured. Data were analyzed using repeated-measures analysis of variance.
resultsAntifungal-loaded bone cement (ALBC) with 10 g poragen delivered more amphotericin B than ALBC containing amphotericin B alone by Day 15, 12.76 μg/cylinder (0.5%) versus 1.74 μg/cylinder (0.04%), respectively. With amphotericin B alone, compressive strength was unchanged and compressive strength did not decrease during elution. Adding 10 g poragen to ALBC with 200 mg amphotericin B decreased the compressive strength and compressive strength decreased further during elution, 80, 61, and 46 MPa at 0, 1, and 30 days, respectively.
conclusionsAmphotericin B is released in very small amounts from antifungal-loaded bone cement. Release can be increased by adding high-dose poragen, but compressive strength decreases sufficiently to limit its use for implant fixation.
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