ArticleCalcified tissue international2011
VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner.
Article in Calcified tissue international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.Endocrine reviews · 2012Pooled it
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- Low-calorie and high-protein diet has diverse impacts on the muscle, bone, and bone marrow adipose tissues.JBMR plus · 2025Article
- Vitamin D: more does not mean better.Archives of endocrinology and metabolism · 2020Article
- Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese.Lipids in health and disease · 2019Article
- High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice.Journal of cellular physiology · 2018Article
- Article
- Low vitamin D status and obesity: Role of nutritionist.Reviews in endocrine & metabolic disorders · 2017Review
- (+)-Cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells by activating vitamin D receptor.Experimental and therapeutic medicine · 2017Article
- Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment.Clinics (Sao Paulo, Brazil) · 2017Article
- Primary Hyperparathyroidism: The Influence of Bone Marrow Adipose Tissue on Bone Loss and of Osteocalcin on Insulin Resistance.Clinics (Sao Paulo, Brazil) · 2016Article
- Exercise Regulation of Marrow Adipose Tissue.Frontiers in endocrinology · 2016Review
- Propranolol Attenuates Risperidone-Induced Trabecular Bone Loss in Female Mice.Endocrinology · 2015Article
- Article
- Vitamin D: link between osteoporosis, obesity, and diabetes?International journal of molecular sciences · 2014Review
- Molecular link between vitamin D and cancer prevention.Nutrients · 2013Review
- Bone Remodeling and Energy Metabolism: New Perspectives.Bone research · 2013Review
- The consequences of growth hormone-releasing hormone receptor haploinsufficiency for bone quality and insulin resistance.Clinical endocrinology · 2012Article
- Vitamin D safety and requirements.Archives of biochemistry and biophysics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The vitamin D receptor (VDR) is crucial for virtually all of vitamin D's actions and is thought to be ubiquitously expressed. We hypothesized that disruption of one allele of the VDR gene would impact bone development and would have metabolic consequences. Body composition and bone mass (BMD) in VDR heterozygous (VDR HET) mice were compared to those obtained in male and female VDR KO and WT mice at 8 weeks of age. Male mice were also evaluated at 16 weeks, and bone marrow mesenchymal stem cell (MSC) differentiation was evaluated in VDR female mice. Additionally, female VDR HET and WT mice received intermittent PTH treatment or vehicle (VH) for 4 weeks. BMD was determined at baseline and after treatment. MRI was done in vivo at the end of treatment; μCT and bone histomorphometry were performed after killing the animals. VDR HET male mice had normal skeletal development until 16 weeks of age but showed significantly less gain in fat mass than WT mice. In contrast, female VDR HET mice showed decreased total-body BMD at age 8 weeks but had a normal skeletal response to PTH. MSC differentiation was also impaired in VDR HET female mice. Thus, female VDR HET mice show early impairment in bone acquisition, while male VDR HET mice exhibit a lean phenotype. Our results indicate that the VDR HET mouse is a useful model for studying the metabolic and skeletal impact of decreased vitamin D sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.