ArticleJournal of neuro-oncology2011
Post-operative radiation improves survival in children younger than 3 years with intracranial ependymoma.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial.Neuro-oncology · 2019Trial
- Three-year insights from a proton therapy centre: Evolving strategies in ependymoma treatment planning.Technical innovations & patient support in radiation oncology · 2025Article
- The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation.Journal of neuro-oncology · 2025Article
- Extensive Leptomeningeal Spreading of Ependymoma in an Adult: Case Report and Literature Review.Brain tumor research and treatment · 2023Article
- Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru.Frontiers in oncology · 2023Article
- Ependymoma: Evaluation and Management Updates.Current oncology reports · 2022Review
- The Current State of Radiotherapy for Pediatric Brain Tumors: An Overview of Post-Radiotherapy Neurocognitive Decline and Outcomes.Journal of personalized medicine · 2022Review
- Intracranial ependymomas: The role of advanced neuroimaging in diagnosis and management.The neuroradiology journal · 2021Review
- Outcome of postoperative radiation therapy for pediatric intracranial ependymoma: a single-institution review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Current and Emerging Methods of Management of Ependymoma.Current oncology reports · 2019Review
- Case-based review: ependymomas in adults.Neuro-oncology practice · 2018Review
- EANO guidelines for the diagnosis and treatment of ependymal tumors.Neuro-oncology · 2018Review
- The role of postoperative radiotherapy in pediatric patients with grade II intracranial ependymomas: a population-based, propensity score-matched study.Cancer management and research · 2018Article
- Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
- Pencil beam scanning proton therapy for pediatric intracranial ependymoma.Journal of neuro-oncology · 2016Article
- Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities.Journal of pediatric hematology/oncology · 2016Review
- Advances in Management of Pediatric Ependymomas.Current oncology reports · 2015Review
- The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Incidence and survival of children with central nervous system primitive tumors in the French National Registry of Childhood Solid Tumors.Neuro-oncology · 2014Article
- Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients.Neuro-oncology · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Concerns regarding long-term toxicities have led to the avoidance of post-operative radiation (PORT) in young children with intracranial ependymoma. We investigated the association between post-operative radiation therapy and overall survival (OS) in children younger than 3 years and compared their survival to other age groups. The study sample from the SEER database included 804 patients with intracranial ependymoma, grades 2-3, and diagnosed between 1988 and 2005. OS was estimated using the Kaplan-Meier method, and hazard ratios (HR) and 95% confidence limits (CL) were calculated based on multivariable Cox proportional hazards models. A total of 804 patients were selected and PORT was administered to 35% of patients younger than 3 years. With a median follow-up of 3 years (range 0.1-18 years), the 3 year OS was 61% for children younger than 3 years, 83% for those ages 3-20 years, and 69% for patients older than 20 years (P < 0.001). In multivariable analysis, OS was significantly improved for patients receiving PORT (HR 0.8, 95% CL 0.6-0.9), and gross total resection (HR 0.6, 95% CL 0.5-0.8). Among children younger than 3 years, the 3 year OS was significantly greater among those who received PORT compared to those who did not (81% vs. 56%, respectively, P = 0.005). The majority of children younger than 3 years with intracranial ependymoma did not receive PORT. Children younger than 3 years who did not receive PORT had a relatively poor outcome, while those who received radiation therapy had a survival similar to older patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.