ArticleMolecular biology reports2012
Cytokine gene polymorphism and asthma susceptibility, progress and control level.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Effects ofFrontiers in genetics · 2022Pooled it
- Interleukin 4 gene polymorphism (-589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies.BMC immunology · 2020Pooled it
- Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity: A Meta-Analysis and Review Under PRISMA Guidelines.Medicine · 2016Pooled it
- Association between promoter polymorphisms of interleukin-4 gene and allergic rhinitis risk: a meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Pooled it
- Significant association between GSTT1 null genotype and risk of asthma during childhood in Caucasians.Molecular biology reports · 2013Pooled it
- Polymorphisms in the interleukin 4 promoter -589C/T gene and the risk of asthma: a systematic review and meta-analysis.Translational pediatrics · 2021Article
- CytokineInternational journal of medical sciences · 2021Observational
- Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma.Canadian respiratory journal · 2021Article
- LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model.Journal of bioenergetics and biomembranes · 2020Article
- Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression.BMC infectious diseases · 2020Article
- Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia.Cancer medicine · 2019Article
- The impact of host's genetic susceptibility on Helicobacter pylori infection in children.Medicine · 2017Article
- Article
- Article
- Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma.Genes and immunity · 2016Article
- Interleukin-6 gene -174G/C polymorphism and bronchial asthma risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Gene susceptibility in Iranian asthmatic patients: a narrative review.Annals of medical and health sciences research · 2014Review
- The role of IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's obesity.European journal of pediatrics · 2014Article
- The Role of Interferon Gamma Gene Polymorphism (+874A/T, +2109A/G, and -183G/T) in Response to Treatment Among Hepatitis C Infected Patients in Fars Province, Southern Iran.Hepatitis monthly · 2014Article
- Cytokine single nucleotide polymorphisms in patients' with gallstone: dose TGF-β gene variants affect gallstone formation?Molecular biology reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a multifactor inflammatory disorder, and its management requires understanding of its various pathogenesis and control mechanisms. Cytokines and other inflammatory mediators are important factors in asthma pathophysiology. In this study, we evaluated the role of cytokine polymorphisms in the asthma susceptibility, progress, control, and lung functions. IL-4-C590T polymorphism by PCR-RFLP method, IFN-γ T+874A, TNF-α-A308G, IL-6 G-174C and TGF-β T+869C variants by ARMS-PCR method and IgE serum level by ELISA technique were determined in 81 asthmatic patients and 124 normal subjects. Asthma diagnosis, treatment and control levels were considered using standard schemes and criteria. TNF-α-308GA genotype was more frequent in asthmatics (P = 0.025, OR 3.352), and polymorphisms between different asthma control levels (P > 0.05) were not different. IFN-γ+874AT genotype had a positive correlation with the familial history of asthma (P = 0.034, OR 2.688). IL-6-174C allele (P = 0.045), TNF-α-308GG genotype (P = 0.002) and TNF-α-308G allele (P = 0.004) showed reduced values, and TNF-α-308GA genotype (P = 0.002) increased FEF25-75 value in asthmatics. IFN-γ+874AA genotype caused a decrease in FVC factor (P = 0.045). This study showed that TNF-α-308GA is a risk factor for asthma, but cytokine gene variants do not affect asthma control and IgE serum levels. Variants producing lower levels of IL-6, TNF-α and IFN-γ are associated with reduced pulmonary capacities. To achieve an appropriate schema for asthma management, further studies with consideration of different aspects in a larger group of patients would be more elucidative.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.