ArticlePloS one2011
Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 83 citations in OpenAlex.
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- Photodynamic Therapy Modulates pri-miRNA Expression inCurrent issues in molecular biology · 2025Article
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- Identification of Oncogene-Induced Senescence-Associated MicroRNAs.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Identification of novel microRNAs in the embryonic mouse brain using deep sequencing.Molecular and cellular biochemistry · 2024Article
- A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions.Frontiers in aging neuroscience · 2022Review
- The Effect of RBP4 on microRNA Expression Profiles in Porcine Granulosa Cells.Animals : an open access journal from MDPI · 2021Article
- Deciphering the role of microRNAs in mustard gas-induced toxicity.Annals of the New York Academy of Sciences · 2021Review
- Network-based analysis implies critical roles of microRNAs in the long-term cellular responses to gold nanoparticles.Nanoscale · 2020Article
- Analysis of microRNA expression profiles in porcine PBMCs after LPS stimulation.Innate immunity · 2020Article
- Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm.Journal of clinical medicine · 2020Article
- MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.Stem cell reviews and reports · 2020Article
- CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5.Neuro-oncology · 2019Article
- Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells.Cell death & disease · 2019Article
- Limited differential expression of miRNAs and other small RNAs in LPS-stimulated human monocytes.PloS one · 2019Article
- MicroRNA controls of cellular senescence.BMB reports · 2018Article
- Diversity and signature of small RNA in different bodily fluids using next generation sequencing.BMC genomics · 2018Article
- Article
- Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests.Nucleic acids research · 2017Article
- Discovery and characterization of the feline miRNAome.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey of miRNA expression and involvement in cell senescence. Informatic analysis of small RNA sequence datasets from young and senescent IMR90 human fibroblasts identifies many miRNAs that are regulated (either up or down) with cell senescence. Comparison with mRNA expression profiles reveals potential mRNA targets of these senescence-regulated miRNAs. The target mRNAs are enriched for genes involved in biological processes associated with cell senescence. This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.