ArticlePloS one2011
Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Influence of 30 and 60 Min of Hypobaric Hypoxia in Simulated Altitude of 15,000 ft on Human Proteome Profile.International journal of molecular sciences · 2022Trial
- Exploring the pentraxin-3 as a prognostic biomarker in paraquat poisoning: a systematic-narrative hybrid review.International journal of emergency medicine · 2025Review
- The Phagocytic Code Regulating Phagocytosis of Mammalian Cells.Frontiers in immunology · 2021Review
- Anti-Pentraxin Antibodies in Autoimmune Diseases: Bystanders or Pathophysiological Actors?Frontiers in immunology · 2020Review
- PTX3 Intercepts Vascular Inflammation in Systemic Immune-Mediated Diseases.Frontiers in immunology · 2019Article
- PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis.Experimental and therapeutic medicine · 2018Article
- Pentraxin 3 and biopsy status in celiac patients.Gastroenterology and hepatology from bed to bench · 2018Article
- Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis.Clinical immunology (Orlando, Fla.) · 2017Review
- Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands.BMC immunology · 2017Article
- Pentraxin 3 deletion aggravates allergic inflammation through a TThe Journal of allergy and clinical immunology · 2017Article
- The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3.Molecular medicine (Cambridge, Mass.) · 2017Article
- Pentraxins in the activation and regulation of innate immunity.Immunological reviews · 2016Review
- The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation?Mediators of inflammation · 2016Review
- Extracellular pattern recognition molecules in health and diseases.Cellular & molecular immunology · 2015Article
- Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus.Autoimmune diseases · 2015Article
- The endothelial deprotection hypothesis for lupus pathogenesis: the dual role of C1q as a mediator of clearance and regulator of endothelial permeability.F1000Research · 2015Article
- Paradoxical effects of all-trans-retinoic acid on lupus-like disease in the MRL/lpr mouse model.PloS one · 2015Article
- A novel chemosynthetic peptide with β-sheet motif efficiently kills Klebsiella pneumoniae in a mouse model.International journal of nanomedicine · 2015Article
- The pathogenesis of lupus nephritis.Journal of the American Society of Nephrology : JASN · 2013Review
- Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease.Journal of clinical immunology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes. Both of these mechanisms are known to be involved in autoimmunity and autoimmune tissue injury, e.g. in systemic lupus erythematosus, but a contribution of PTX3 is hypothetical. To evaluate a potential immunoregulatory role of PTX3 in autoimmunity we crossed Ptx3-deficient mice with Fas-deficient (lpr) C57BL/6 (B6) mice with mild lupus-like autoimmunity. PTX3 was found to be increasingly expressed in kidneys and lungs of B6lpr along disease progression. Lack of PTX3 impaired the phagocytic uptake of apoptotic T cells into peritoneal macrophages and selectively expanded CD4/CD8 double negative T cells while other immune cell subsets and lupus autoantibody production remained unaffected. Lack of PTX3 also aggravated autoimmune lung disease, i.e. peribronchial and perivascular CD3+ T cell and macrophage infiltrates of B6lpr mice. In contrast, histomorphological and functional parameters of lupus nephritis remained unaffected by the Ptx3 genotype. Together, PTX3 specifically suppresses autoimmune lung disease that is associated with systemic lupus erythematosus. Vice versa, loss-of-function mutations in the Ptx3 gene might represent a genetic risk factor for pulmonary (but not renal) manifestations of systemic lupus or other autoimmune diseases.
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