ArticlePloS one2011
Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 136 citations in OpenAlex.
- Immunolocalization of anti-Mullerian hormone in bovine testes and ovaries during fetal development.Animal reproduction · 2026Article
- AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.Communications biology · 2025Article
- Anti-mullerian hormone (AMH) in pregnant buffaloes: maternal and fetal plasma concentrations and immunolocalization in the fetal gonads.Animal reproduction · 2025Article
- The role of vitamin D3 in follicle development.Journal of ovarian research · 2024Review
- Article
- The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests.Communications biology · 2023Article
- Nonylphenol Exposure-Induced Oocyte Quality Deterioration Could be Reversed by Boric Acid Supplementation in Rats.Biological trace element research · 2023Article
- Obesity is associated with alterations in antral follicle dynamics in eumenorrheic women.Human reproduction (Oxford, England) · 2023Observational
- Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review.Reproductive biology and endocrinology : RB&E · 2022Review
- TGFß Gene Members and Their Regulatory Factors in Granulosa Compared to Cumulus Cells in PCOS: A Case-Control Study.Cell journal · 2022Article
- Insights into in vivo follicle formation: a review of in vitro systems.Histochemistry and cell biology · 2022Review
- Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- The ovarian reserve as target of insulin/IGF and ROS in metabolic disorder-dependent ovarian dysfunctions.Reproduction & fertility · 2021Review
- Capitalizing on transcriptome profiling to optimize and identify targets for promoting early murine folliculogenesis in vitro.Scientific reports · 2021Article
- Control of ovarian follicle development by TGFβ family signaling.Current opinion in endocrine and metabolic research · 2021Article
- Single-cell sequencing reveals suppressive transcriptional programs regulated by MIS/AMH in neonatal ovaries.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Blocking estrogen-induced AMH expression is crucial for normal follicle formation.Development (Cambridge, England) · 2021Article
- Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan.Frontiers in reproductive health · 2021Review
- Follicle Rescue From Prepubertal Ovaries After Recent Treatment With Cyclophosphamide-An Experimental Culture System Using Mice to Achieve Mature Oocytes for Fertility Preservation.Frontiers in oncology · 2021Article
- Increased supply from blood vessels promotes the activation of dormant primordial follicles in mouse ovaries.The Journal of reproduction and development · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study was designed to investigate the actions of Anti-Müllerian Hormone (AMH) on primordial follicle assembly. Ovarian primordial follicles develop from the breakdown of oocyte nests during fetal development for the human and immediately after birth in rodents. AMH was found to inhibit primordial follicle assembly and decrease the initial primordial follicle pool size in a rat ovarian organ culture. The AMH expression was found to be primarily in the stromal tissue of the ovaries at this period of development, suggesting a stromal-epithelial cell interaction for primordial follicle assembly. AMH was found to promote alterations in the ovarian transcriptome during primordial follicle assembly with over 200 genes with altered expression. A gene network was identified suggesting a potential central role for the Fgf2/Nudt6 antisense transcript in the follicle assembly process. A number of signal transduction pathways are regulated by AMH actions on the ovarian transcriptome, in particular the transforming growth factor-beta (TGFß) signaling process. AMH is the first hormone/protein shown to have an inhibitory action on primordial follicle assembly. Due to the critical role of the primordial follicle pool size for female reproduction, elucidation of factors, such as AMH, that regulate the assembly process will provide insights into potential therapeutics to manipulate the pool size and female reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.