ArticleGenetics and molecular biology2010
In silicio expression analysis of PKS genes isolated from Cannabis sativa L.
Article in Genetics and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Application of SITS in the Electrochemical Biosensor Method for Characterization of Substrate Transport into Microbial Cells.Current microbiology · 2026Article
- THC and CBD Fingerprinting of an Elite Cannabis Collection from Iran: Quantifying Diversity to Underpin Future Cannabis Breeding.Plants (Basel, Switzerland) · 2022Article
- Low temperature modifies seedling leaf anatomy and gene expression inFrontiers in plant science · 2022Article
- Editorial: Cannabis Genomics, Breeding and Production.Frontiers in plant science · 2020Article
- A new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis.Scientific reports · 2018Article
- Article
- Ectopic expression and functional characterization of type III polyketide synthase mutants from Emblica officinalis Gaertn.Plant cell reports · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cannabinoids, flavonoids, and stilbenoids have been identified in the annual dioecious plant Cannabis sativa L. Of these, the cannabinoids are the best known group of this plant's natural products. Polyketide synthases (PKSs) are responsible for the biosynthesis of diverse secondary metabolites, including flavonoids and stilbenoids. Biosynthetically, the cannabinoids are polyketide substituted with terpenoid moiety. Using an RT-PCR homology search, PKS cDNAs were isolated from cannabis plants. The deduced amino acid sequences showed 51%-73% identity to other CHS/STS type sequences of the PKS family. Further, phylogenetic analysis revealed that these PKS cDNAs grouped with other non-chalcone-producing PKSs. Homology modeling analysis of these cannabis PKSs predicts a 3D overall fold, similar to alfalfa CHS2, with small steric differences on the residues that shape the active site of the cannabis PKSs.
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Registered trials
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