ArticleGenetics and molecular biology2009
Population prevalence of hereditary breast cancer phenotypes and implementation of a genetic cancer risk assessment program in southern Brazil.
Article in Genetics and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Trial
- Germline molecular data in hereditary breast cancer in Brazil: Lessons from a large single-center analysis.PloS one · 2021Article
- Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies.International journal of environmental research and public health · 2020Review
- Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer.Cancer medicine · 2017Article
- Article
- Self-reported cancer family history is a useful tool for identification of individuals at risk of hereditary cancer predisposition syndrome at primary care centers in middle-income settings: a longitudinal study.Genetics and molecular biology · 2016Article
- Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil.Genetics and molecular biology · 2016Article
- Translating Population Difference: The Use and Re-Use of Genetic Ancestry in Brazilian Cancer Genetics.Medical anthropology · 2016Article
- Knowledge about hereditary cancer of women with family histories of breast, colorectal, or both types of cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2015Article
- Hereditary cancer syndromes: opportunities and challenges.BMC proceedings · 2013Article
- Establishing a program for individuals at high risk for breast cancer.Journal of Cancer · 2013Article
- Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care.BMC cancer · 2009Article
- A model to optimize public health care and downstage breast cancer in limited-resource populations in southern Brazil. (Porto Alegre Breast Health Intervention Cohort).BMC public health · 2009Article
- Knowledge about breast cancer and hereditary breast cancer among nurses in a public hospital.Revista latino-americana de enfermagemArticle
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2004, a population-based cohort (the Núcleo Mama Porto Alegre - NMPOA Cohort) was started in Porto Alegre, southern Brazil and within that cohort, a hereditary breast cancer study was initiated, aiming to determine the prevalence of hereditary breast cancer phenotypes and evaluate acceptance of a genetic cancer risk assessment (GCRA) program. Women from that cohort who reported a positive family history of cancer were referred to GCRA. Of the 9218 women enrolled, 1286 (13.9%) reported a family history of cancer. Of the 902 women who attended GCRA, 55 (8%) had an estimated lifetime risk of breast cancer ≥ 20% and 214 (23.7%) had pedigrees suggestive of a breast cancer predisposition syndrome; an unexpectedly high number of these fulfilled criteria for Li-Fraumeni-like syndrome (122 families, 66.7%). The overall prevalence of a hereditary breast cancer phenotype was 6.2% (95%CI: 5.67-6.65). These findings identified a problem of significant magnitude in the region and indicate that genetic cancer risk evaluation should be undertaken in a considerable proportion of the women from this community. The large proportion of women who attended GCRA (72.3%) indicates that the program was well-accepted by the community, regardless of the potential cultural, economic and social barriers.
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