ArticleGenetics and molecular biology2010
Effect of polymorphisms in the Slc11a1 coding region on resistance to brucellosis by macrophages in vitro and after challenge in two Bos breeds (Blanco Orejinegro and Zebu).
Article in Genetics and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Association Analysis ofAnimals : an open access journal from MDPI · 2025Article
- Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat.Irish veterinary journal · 2025Article
- Genomic insights into the population history and adaptive traits of Latin American Criollo cattle.Royal Society open science · 2024Article
- New insights into the genetic predisposition of brucellosis and its effect on the gut and vaginal microbiota in goats.Scientific reports · 2023Article
- Deletion in KARLN intron 5 and predictive relationship with bovine tuberculosis and brucellosis infection phenotype.Veterinary research communications · 2023Article
- Optimization of high molecular weight DNA extraction methods in shrimp for a long-read sequencing platform.PeerJ · 2020Article
- Tick burden in Bos taurus cattle and its relationship with heat stress in three agroecological zones in the tropics of Colombia.Parasites & vectors · 2019Article
- Genome to Phenome: Improving Animal Health, Production, and Well-Being - A New USDA Blueprint for Animal Genome Research 2018-2027.Frontiers in genetics · 2019Article
- Association between human brucellosis and adverse pregnancy outcome: a cross-sectional population-based study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Quantification and comparison of TLR2 activity in monocyte-derived macrophages of zebu and crossbred cattle.Iranian journal of veterinary research · 2018Article
- Sero-epidemiological survey and risk factors associated with bovine brucellosis among slaughtered cattle in Nigeria.The Onderstepoort journal of veterinary research · 2016Article
- Influence of endogamy and mitochondrial DNA on immunological parameters in cattle.BMC veterinary research · 2014Article
- Genetic analysis of the 3' untranslated region of the bovine SLC11A1 gene reveals novel polymorphisms.Molecular biology reports · 2013Article
- A large seroprevalence survey of brucellosis in cattle herds under diverse production systems in northern Nigeria.BMC veterinary research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The resistance/susceptibility of selected cattle breeds to brucellosis was evaluated in an F1 population generated by crossing animals classified as resistant (R) and susceptible (S) (R x R, R x S, S x R, S x S) based on challenges in vitro and in vivo. The association between single nucleotide polymorphisms identified in the coding region of the Slc11a1 gene and resistance/susceptibility was estimated. The trait resistance or susceptibility to brucellosis, evaluated by a challenge in vitro, showed a high heritable component in terms of additive genetic variance (h(2) = 0.54 ± 0.11). In addition, there was a significant association (p < 0.05) between the control of bacterial survival and two polymorphisms (a 3'UTR and SNP4 located in exon 10). The antibody response of animals classified as resistant to infection by Brucella abortus differed significantly (p < 0.05) from that of susceptible animals. However, there was no significant association between single nucleotide polymorphisms located in the Slc11a1 gene and the antibody response stimulated by a challenge in vivo.
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