ArticlePloS one2011
Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- The intersection of disorders of sex development and cardiovascular diseases.Biology of sex differences · 2026Review
- The single-cell chromatin landscape in gonadal cell lineage specification.BMC genomics · 2024Article
- Genomic Prediction and Genome-Wide Association Study for Boar Taint Compounds.Animals : an open access journal from MDPI · 2023Article
- Early Gonadal Development and Sex Determination in Mammal.International journal of molecular sciences · 2022Review
- Associations of Transcription Factor 21 Gene Polymorphisms with the Growth and Body Composition Traits in Broilers.Animals : an open access journal from MDPI · 2022Article
- TCF21Nature communications · 2021Article
- Sex-Determining Region Y Controls the Effects of Fetal Alcohol Exposure on Proopiomelanocortin Gene Expression.Frontiers in neuroscience · 2021Article
- Role of the bHLH transcription factor TCF21 in development and tumorigenesis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Review
- TCF21: a critical transcription factor in health and cancer.Journal of molecular medicine (Berlin, Germany) · 2020Review
- Haplotype-based genome-wide association studies for carcass and growth traits in chicken.Poultry science · 2020Article
- Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.Science (New York, N.Y.) · 2019Article
- Sexual dimorphism in brain transcriptomes of Amami spiny rats (Tokudaia osimensis): a rodent species where males lack the Y chromosome.BMC genomics · 2019Article
- Analysis of Long Non-Coding RNA and mRNA Expression Profiling in Immature and Mature Bovine (Frontiers in genetics · 2019Article
- TCF21 is related to testis growth and development in broiler chickens.Genetics, selection, evolution : GSE · 2017Article
- Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?Frontiers in neuroscience · 2017Review
- The distribution and adipogenic potential of perivascular adipose tissue adipocyte progenitors is dependent on sexual dimorphism and vessel location.Physiological reports · 2016Article
- Environmentally Induced Epigenetic Transgenerational Inheritance of Altered SRY Genomic Binding During Gonadal Sex Determination.Environmental epigenetics · 2015Article
- E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.Developmental cell · 2015Review
- Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer.Journal of cancer research and clinical oncology · 2015Article
- Regulation of male sex determination: genital ridge formation and Sry activation in mice.Cellular and molecular life sciences : CMLS · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cascade of molecular events involved in mammalian sex determination has been shown to involve the SRY gene, but specific downstream events have eluded researchers for decades. The current study identifies one of the first direct downstream targets of the male sex determining factor SRY as the basic-helix-loop-helix (bHLH) transcription factor TCF21. SRY was found to bind to the Tcf21 promoter and activate gene expression. Mutagenesis of SRY/SOX9 response elements in the Tcf21 promoter eliminated the actions of SRY. SRY was found to directly associate with the Tcf21 promoter SRY/SOX9 response elements in vivo during fetal rat testis development. TCF21 was found to promote an in vitro sex reversal of embryonic ovarian cells to induce precursor Sertoli cell differentiation. TCF21 and SRY had similar effects on the in vitro sex reversal gonadal cell transcriptomes. Therefore, SRY acts directly on the Tcf21 promoter to in part initiate a cascade of events associated with Sertoli cell differentiation and embryonic testis development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.