ArticleJournal of orthopaedic trauma2011
Decreasing bacterial colonization of external fixation pins through nitric oxide release coatings.
Article in Journal of orthopaedic trauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- A systematic review of animal models for Staphylococcus aureus osteomyelitis.European cells & materials · 2014Pooled it
- Emerging strategies for the prevention of bacterial biofilm in prosthetic surgery.Translational andrology and urology · 2024Review
- Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis.International journal of molecular sciences · 2023Article
- Fungal-derived selenium nanoparticles and their potential applications in electroless silver coatings for preventing pin-tract infections.Regenerative biomaterials · 2022Article
- Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design.JOR spine · 2021Review
- CORR Insights®: Does Preoperative Decolonization Reduce Surgical Site Infections in Elective Orthopaedic Surgery? A Prospective Randomized Controlled Trial.Clinical orthopaedics and related research · 2020Article
- Nanomaterial Nitric Oxide Delivery in Traumatic Orthopedic Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- In Vivo Antibacterial Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers againstMolecular pharmaceutics · 2019Article
- Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair.Progress in materials science · 2017Article
- Antimicrobial Activity of Nitric Oxide-Releasing Ti-6Al-4V Metal Oxide.Journal of functional biomaterials · 2017Article
- From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation.Journal of children's orthopaedics · 2016Review
- Antibacterial potency of different deposition methods of silver and copper containing diamond-like carbon coated polyethylene.Biomaterials research · 2016Article
- Antibacterial efficacy of titanium-containing alloy with silver-nanoparticles enriched diamond-like carbon coatings.AMB Express · 2015Article
- Antibacterial efficacy of ultrahigh molecular weight polyethylene with silver containing diamond-like surface layers.AMB Express · 2015Article
- Nitric oxide as a surgical adjuvant.Future science OA · 2015Review
- Nitric oxide-flux dependent bacterial adhesion and viability at fibrinogen-coated surfaces.Biomaterials science · 2013Article
- Nitric oxide-releasing xerogels synthesized from N-diazeniumdiolate-modified silane precursors.ACS applied materials & interfaces · 2013Article
- Establishment of a femoral critical-size bone defect model in immunodeficient mice.The Journal of surgical research · 2013Article
- Local delivery of nitric oxide: targeted delivery of therapeutics to bone and connective tissues.Advanced drug delivery reviews · 2012Review
- Analysis of the release characteristics of cu-treated antimicrobial implant surfaces using atomic absorption spectrometry.Bioinorganic chemistry and applications · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBacterial infection of the pin tract represents the most common complication associated with external fixation. This study was designed to evaluate the antibacterial activity of nitric oxide (NO)-releasing xerogel films applied to commercially pure titanium pins in a rat model.
methodsPins were coated with xerogel solution through a dip-coating procedure. Half of the xerogel-coated implant pins were modified into NO donors and served as the NO-releasing group, whereas the remaining pins were left unmodified to serve as non-NO-releasing xerogel-coated controls. Acid-etched pins served as uncoated controls. Animal selection was randomized and every rat had one pin from each of the three groups randomly allocated to the third, fourth, or fifth tail vertebrae. Quantification of bacterial infection was performed 48 days postoperatively and the tissue-implant interface was inspected for clinical signs of infection on Days 14 and 28 postimplantation.
resultsPin tract bacterial colony counts of the NO-releasing group (170,000 ± 181,000) were significantly lower than both the xerogel-coated group (677,000 ± 675,000) and the control group (1,181,000 ± 2,717,000) 48 days postoperatively (P < 0.05). No significant difference in colony counts was observed between the xerogel-coated group and the control group. The NO-releasing group also had significantly fewer clinical signs of infection than both the coated and the control groups on postoperative Day 28 (P < 0.05).
conclusionThe application of NO-releasing xerogel coatings can inhibit bacterial colonization of external fixation pins both during the initial postsurgical period and up to 48 days postimplantation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.