ArticleBioengineered bugs
Escherichia coli K5 heparosan fermentation and improvement by genetic engineering.
Article in Bioengineered bugs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed.
- Enhanced heparosan biosynthesis in Corynebacterium glutamicum by systematic metabolic engineering and translation-level fine-tuning.Bioresources and bioprocessing · 2026Article
- Coupling optimization of cell growth cycle and key enzyme membrane localization for enhanced synthesis of high molecular weight heparosan by Corynebacterium glutamicum.Bioresources and bioprocessing · 2025Article
- Expression and Purification of Cp3GT: Structural Analysis and Modeling of a Key Plant Flavonol-3-O Glucosyltransferase fromBiotech (Basel (Switzerland)) · 2024Article
- Simultaneous production ofHeliyon · 2023Article
- Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing.Synthetic and systems biotechnology · 2023Review
- A programmable encapsulation system improves delivery of therapeutic bacteria in mice.Nature biotechnology · 2022Article
- Nanoparticle Surface Engineering with Heparosan Polysaccharide Reduces Serum Protein Adsorption and Enhances Cellular Uptake.Nano letters · 2022Article
- Heterologous production of chondroitin.Biotechnology reports (Amsterdam, Netherlands) · 2022Review
- Review
- Bioengineered production of glycosaminoglycans and their analogues.Systems microbiology and biomanufacturing · 2021Article
- A Revised Structure for the Glycolipid Terminus ofBiomolecules · 2020Article
- Chemical O-sulfation of N-sulfoheparosan: a route to rare N-sulfo-3-O-sulfoglucosamine and 2-O-sulfoglucuronic acid.Glycoconjugate journal · 2020Article
- New Means to Control Molecular Assembly.The journal of physical chemistry. C, Nanomaterials and interfaces · 2020Article
- Engineered heparins as new anticoagulant drugs.Bioengineering & translational medicine · 2017Review
- Bioengineered heparins and heparan sulfates.Advanced drug delivery reviews · 2016Review
- Cyclic AMP (cAMP) Receptor Protein-cAMP Complex Regulates Heparosan Production in Escherichia coli Strain Nissle 1917.Applied and environmental microbiology · 2015Article
- Assays for determining heparan sulfate and heparin O-sulfotransferase activity and specificity.Analytical and bioanalytical chemistry · 2014Article
- Exopolysaccharides produced by marine bacteria and their applications as glycosaminoglycan-like molecules.Frontiers in chemistry · 2014Review
- Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains.Glycobiology · 2013Review
- High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production.Applied microbiology and biotechnology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
N-acetyl heparosan is the precursor for the biosynthesis of the important anticoagulant drug heparin. The E. coli K5 capsular heparosan polysaccharide provides a promising precursor for in vitro chemoenzymatic production of bioengineered heparin. This article explores the improvements of heparosan production for bioengineered heparin by fermentation process engineering and genetic engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.