ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Antihypertensive Use and the Effect of a Physical Activity Intervention in the Prevention of Major Mobility Disability Among Older Adults: The LIFE Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Multi-modal intervention to reduce cardiovascular risk among hypertensive older adults: Design of a randomized clinical trial.Contemporary clinical trials · 2015Trial
- Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise.Journal of the American Geriatrics Society · 2012Trial
- A Pragmatic Two-Step Screening Algorithm for Sarcopenia and Frailty in Community-Dwelling Older Adults: A Cross-Sectional Population-Based Study.Life (Basel, Switzerland) · 2026Article
- Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors.Frontiers in cell and developmental biology · 2024Article
- Angiotensin (1-7) Delivered Orally via Probiotic in Combination With Exercise: Sex-Dependent Influence on Health Span.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats.Frontiers in rehabilitation sciences · 2021Article
- Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide.Metabolomics : Official journal of the Metabolomic Society · 2019Review
- Multimodal Intervention to Improve Functional Status in Hypertensive Older Adults: A Pilot Randomized Controlled Trial.Journal of clinical medicine · 2019Article
- Article
- Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice.Aging · 2018Article
- Comparative Approaches to Understanding the Relation Between Aging and Physical Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Review
- Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.The Journal of physiology · 2016Review
- Hypertension and aging.Ageing research reviews · 2016Review
- Successful aging: Advancing the science of physical independence in older adults.Ageing research reviews · 2015Review
- The renin-angiotensin system and prevention of age-related functional decline: where are we now?Age (Dordrecht, Netherlands) · 2015Review
- Article
- Optimizing the benefits of exercise on physical function in older adults.PM & R : the journal of injury, function, and rehabilitation · 2014Review
- Battery of behavioral tests in mice that models age-associated changes in human motor function.Age (Dordrecht, Netherlands) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Caloric restriction and physical exercise have proven beneficial against age-associated changes in body composition and declining physical performance; however, little is known regarding what benefit these interventions might have when initiated late in life. The study of mimetics of diet and exercise and the combination thereof may provide additional treatments for a vulnerable elderly population; however, how and when to initiate such interventions requires consideration in developing the most safe and efficacious treatment strategies. In this review, we focus on preclinical late-life intervention studies, which assess the relationship between physical function, sarcopenia, and body composition. We provide a conceptual framework for the ever-changing definition of sarcopenia and a rationale for the use of an appropriate rodent model of this condition. We finish by providing our perspective regarding the implications of this body of work and future areas of research that may also contribute to the ultimate goal of extending healthspan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.