ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011
Giant sucking sound: can physiology fill the intellectual void left by the reductionists?
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The 'lactate paradox' revisited after 35 years: In memoriam Paolo Cerretelli.Experimental physiology · 2026Review
- Mimicking exercise: what matters most and where to next?The Journal of physiology · 2021Review
- Metabolic Myopathies: "Human Knockout" Models and Translational Medicine.Frontiers in physiology · 2020Article
- Physiology and technology for the ICU in vivo.Critical care (London, England) · 2019Review
- Syncopedia: training a new generation of syncope specialists.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Article
- Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model.Journal of visualized experiments : JoVE · 2017Article
- From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.NPJ microgravity · 2017Article
- The clinical translation gap in child health exercise research: a call for disruptive innovation.Clinical and translational science · 2015Article
- Epigenetics in comparative biology: why we should pay attention.Integrative and comparative biology · 2014Review
- Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecholamine systems.Comprehensive Physiology · 2013Review
- Maximizing information from space data resources: a case for expanding integration across research disciplines.European journal of applied physiology · 2013Review
- Cardiac output, at rest and during exercise, before and during myocardial ischemia, reperfusion, and infarction in conscious mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Biologic complexity in sickle cell disease: implications for developing targeted therapeutics.TheScientificWorldJournal · 2013Review
- Physiology: found in translation.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular reductionism has so far failed to deliver the broad-based therapeutic insights that were initially hoped for. This form of reductionism is now being replaced by so-called "systems biology." This is a nebulously defined approach and/or discipline, with some versions of it relying excessively on hypothesis-neutral approaches and only minimally informed by key physiological concepts such as homeostasis and regulation. In this context, physiology is uniquely positioned to continue to provide impressive levels of both biological and therapeutic insight by using hypothesis-driven "classical" approaches and concepts to help frame what might be described as the "pieces of the puzzle" that emerge from molecular reductionism. The strength of physiology as a "bridge" between reductionism and epidemiology, along with its unparalleled ability to generate therapeutic insights and opportunities justifies increased attention and emphasis on our discipline into the future. Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.