ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation.Science robotics · 2023Article
- Animal Models for Functional Gastrointestinal Disorders.Frontiers in psychiatry · 2020Review
- The Role of Ghrelin in Anorexia Nervosa.International journal of molecular sciences · 2018Review
- Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.Frontiers in endocrinology · 2018Review
- Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats.Journal of neurogastroenterology and motility · 2017Article
- Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones.Biology of sex differences · 2017Article
- A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood.Journal of visualized experiments : JoVE · 2016Article
- Role of Brain NUCB2/nesfatin-1 in the Stress-induced Modulation of Gastrointestinal Functions.Current neuropharmacology · 2016Review
- Article
- Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito.PloS one · 2015Article
- Brain peptides and the modulation of postoperative gastric ileus.Current opinion in pharmacology · 2014Review
- Peripheral α2-β1 adrenergic interactions mediate the ghrelin response to brain urocortin 1 in rats.Psychoneuroendocrinology · 2014Article
- High-protein diet selectively reduces fat mass and improves glucose tolerance in Western-type diet-induced obese rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Article
- Gastric peptides and their regulation of hunger and satiety.Current gastroenterology reports · 2012Article
- Yin and Yang - the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake.Journal of neurogastroenterology and motility · 2012Article
- Ghrelin - a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach.Frontiers in neuroscience · 2012Article
- Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications.Frontiers in endocrinology · 2012Article
- Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications.Peptides · 2011Review
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7 authors.
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Abstract
Clinical studies are evaluating the efficacy of synthetic ghrelin agonists in postoperative ileus management. However, the control of ghrelin secretion under conditions of postoperative gastric ileus is largely unknown. Peripheral somatostatin inhibits ghrelin secretion in animals and humans. We investigated the time course of ghrelin changes postsurgery in fasted rats and whether somatostatin receptor subtype 2 (sst(2)) signaling is involved. Abdominal surgery (laparotomy and 1-min cecal palpation) induced a rapid and long-lasting decrease in plasma acyl ghrelin levels as shown by the 64, 67, and 59% reduction at 0.5, 2, and 5 h postsurgery, respectively, compared with sham (anesthesia alone for 10 min, P < 0.05). Levels were partly recovered at 7 h and fully restored at 24 h. The percentage of acyl ghrelin reduction was significantly higher than that of desacyl ghrelin at 2 h postsurgery and not at any other time point. This was associated with a 48 and 23% decrease in gastric and plasma ghrelin-O-acyltransferase protein concentrations, respectively (P < 0.001). Ghrelin-positive cells in the oxyntic mucosa expressed sst(2a) receptor and the sst(2) agonist S-346-011 inhibited fasting acyl ghrelin levels by 64 and 77% at 0.5 and 2 h, respectively. The sst(2) antagonist S-406-028 prevented the abdominal surgery-induced decreased circulating acyl ghrelin but not the delayed gastric emptying assessed 0.5 h postinjection. These data show that activation of sst(2) receptor located on gastric X/A-like cells plays a key role in the rapid inhibition of circulating acyl ghrelin induced by abdominal surgery while not being primarily involved in the early phase of postoperative gastric ileus.
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