ArticleEnvironmental research2011
Organophosphate pesticide metabolite levels in pre-school children in an agricultural community: within- and between-child variability in a longitudinal study.
Article in Environmental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Systematic Literature Review of the Take-Home Route of Pesticide Exposure via Biomonitoring and Environmental Monitoring.International journal of environmental research and public health · 2019Pooled it
- Urinary Glyphosate Concentrations among Pregnant Participants in a Randomized, Crossover Trial of Organic and Conventional Diets.Environmental health perspectives · 2023Trial
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings.Toxics · 2025Article
- The Effect of Pesticide Spray Season and Residential Proximity to Agriculture on Glyphosate Exposure among Pregnant People in Southern Idaho, 2021.Environmental health perspectives · 2023Article
- Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.Environmental research · 2022Article
- Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides.Journal of exposure science & environmental epidemiology · 2020Article
- Application of improved approach to evaluate a community intervention to reduce exposure of young children living in farmworker households to organophosphate pesticides.Journal of exposure science & environmental epidemiology · 2019Article
- Urinary pesticide concentrations in French adults with low and high organic food consumption: results from the general population-based NutriNet-Santé.Journal of exposure science & environmental epidemiology · 2019Observational
- Evaluation of the relationship between residential orchard density and dimethyl organophosphate pesticide residues in house dust.Journal of exposure science & environmental epidemiology · 2019Article
- Characterization of organophosphate pesticides in urine and home environment dust in an agricultural community.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2018Article
- Acetylcholinesterase activity and time after a peak pesticide-use period among Ecuadorian children.International archives of occupational and environmental health · 2018Article
- Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children.Mutation research. Genetic toxicology and environmental mutagenesis · 2017Article
- Seasonal and occupational trends of five organophosphate pesticides in house dust.Journal of exposure science & environmental epidemiology · 2017Article
- Urinary microRNAs as potential biomarkers of pesticide exposure.Toxicology and applied pharmacology · 2016Article
- Organophosphate Pesticide Urinary Metabolites Among Latino Immigrants: North Carolina Farmworkers and Non-farmworkers Compared.Journal of occupational and environmental medicine · 2016Article
- Organophosphate Insecticide Metabolites in Prenatal and Childhood Urine Samples and Intelligence Scores at 6 Years of Age: Results from the Mother-Child PELAGIE Cohort (France).Environmental health perspectives · 2016Article
- Population-based comparison of biomarker concentrations for chemicals of concern among Latino-American and non-Hispanic white children.Journal of immigrant and minority health · 2015Article
- Estimating pesticide exposure from dietary intake and organic food choices: the Multi-Ethnic Study of Atherosclerosis (MESA).Environmental health perspectives · 2015Article
- Macro-activity patterns of farmworker and non-farmworker children living in an agricultural community.Environmental research · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This study characterized the within- and between-child variability in dimethylthiophosphate (DMTP) levels in the urine of 44 children living in an agricultural community in central Washington State in December 1997 and 1999. The goal of this analysis was to investigate these variability components during periods when organophosphate pesticides were and were not actively applied to orchards in that community. Each child provided between 10 and 26 biweekly urine samples over a 21-month period, and these samples were analyzed for six dialkylphosphate (DAP) metabolites common to organophosphate pesticides, including DMTP. Previous analysis of this dataset found that DAP concentrations were elevated during months when organophosphate pesticides were applied to orchards in this region. The current analysis demonstrates that the within-child component of day-to-day variability was much greater than the between-child component of variability by a factor of 3-7 across the DAP metabolites that were analyzed. Therefore, organophosphate pesticide exposure appeared to vary more than 3 times from day-to-day than from child-to-child. This finding has important implications for epidemiologic and exposure pathways research, since accounting for within-child variability may increase the power of a study and allow for the detection of differences that would not otherwise be possible without an analysis that separates out the within-child variability.
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Registered trials
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