ArticleBMC genomics2011
Site-specific mobilization of vinyl chloride respiration islands by a mechanism common in Dehalococcoides.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Long-term survival ofFEMS microbes · 2022Article
- Tetrachloroethene respiration in Sulfurospirillum species is regulated by a two-component system as unraveled by comparative genomics, transcriptomics, and regulator binding studies.MicrobiologyOpen · 2020Article
- Roles of Organohalide-RespiringmSystems · 2020Article
- Review
- Complete Genome Sequence of Dehalococcoides mccartyi Strain WBC-2, Capable of Anaerobic Reductive Dechlorination of Vinyl Chloride.Genome announcements · 2016Article
- Comparative Single-Cell Genomics of Chloroflexi from the Okinawa Trough Deep-Subsurface Biosphere.Applied and environmental microbiology · 2016Article
- Dehalogenimonas sp. Strain WBC-2 Genome and Identification of Its trans-Dichloroethene Reductive Dehalogenase, TdrA.Applied and environmental microbiology · 2016Article
- Organohalide Respiring Bacteria and Reductive Dehalogenases: Key Tools in Organohalide Bioremediation.Frontiers in microbiology · 2016Review
- Genome sequence of the organohalide-respiring Dehalogenimonas alkenigignens type strain (IP3-3(T)).Standards in genomic sciences · 2016Article
- A comparative genomics and reductive dehalogenase gene transcription study of two chloroethene-respiring bacteria, Dehalococcoides mccartyi strains MB and 11a.Scientific reports · 2015Article
- Complete genome sequencing of Dehalococcoides sp. strain UCH007 using a differential reads picking method.Standards in genomic sciences · 2015Article
- Single cell genomic study of Dehalococcoidetes species from deep-sea sediments of the Peruvian Margin.The ISME journal · 2014Article
- Identification and environmental distribution of dcpA, which encodes the reductive dehalogenase catalyzing the dichloroelimination of 1,2-dichloropropane to propene in organohalide-respiring chloroflexi.Applied and environmental microbiology · 2014Article
- Identification of a reductive tetrachloroethene dehalogenase in Shewanella sediminis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Comparative metagenomics of three Dehalococcoides-containing enrichment cultures: the role of the non-dechlorinating community.BMC genomics · 2012Article
- Complete genome sequence of Dehalogenimonas lykanthroporepellens type strain (BL-DC-9(T)) and comparison to "Dehalococcoides" strains.Standards in genomic sciences · 2012Article
- Genomic determinants of organohalide-respiration in Geobacter lovleyi, an unusual member of the Geobacteraceae.BMC genomics · 2012Article
- Transcriptional analysis of a Dehalococcoides-containing microbial consortium reveals prophage activation.Applied and environmental microbiology · 2012Article
- Ecogenomics of microbial communities in bioremediation of chlorinated contaminated sites.Frontiers in microbiology · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundVinyl chloride is a widespread groundwater pollutant and Group 1 carcinogen. A previous comparative genomic analysis revealed that the vinyl chloride reductase operon, vcrABC, of Dehalococcoides sp. strain VS is embedded in a horizontally-acquired genomic island that integrated at the single-copy tmRNA gene, ssrA.
resultsWe targeted conserved positions in available genomic islands to amplify and sequence four additional vcrABC -containing genomic islands from previously-unsequenced vinyl chloride respiring Dehalococcoides enrichments. We identified a total of 31 ssrA-specific genomic islands from Dehalococcoides genomic data, accounting for 47 reductive dehalogenase homologous genes and many other non-core genes. Sixteen of these genomic islands contain a syntenic module of integration-associated genes located adjacent to the predicted site of integration, and among these islands, eight contain vcrABC as genetic 'cargo'. These eight vcrABC -containing genomic islands are syntenic across their ~12 kbp length, but have two phylogenetically discordant segments that unambiguously differentiate the integration module from the vcrABC cargo. Using available Dehalococcoides phylogenomic data we estimate that these ssrA-specific genomic islands are at least as old as the Dehalococcoides group itself, which in turn is much older than human civilization.
conclusionsThe vcrABC -containing genomic islands are a recently-acquired subset of a diverse collection of ssrA-specific mobile elements that are a major contributor to strain-level diversity in Dehalococcoides, and may have been throughout its evolution. The high similarity between vcrABC sequences is quantitatively consistent with recent horizontal acquisition driven by ~100 years of industrial pollution with chlorinated ethenes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.