Evidence map›Paper›PMID 21635634›Full record

SynthesisDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]2011

Skin cancer arising in scars: a systematic review.

Sarah C Wallingford, Catherine M Olsen, Elsemieke Plasmeijer, Adèle C Green

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. [Indications, selection, and effect of flap application in repairing scar carcinoma in the lower leg and ankle].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021
    Article
  5. Article
  6. Article
  7. Comprehensive Analysis of Long Noncoding RNAs and Messenger RNAs Expression Profiles in Patients with Marjolin Ulcer.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Sarah C WallingfordSchool of Translational Medicine, Manchester Academic Health Sciences Centre, University of Manchester, United Kingdom.
Catherine M Olsen
Elsemieke Plasmeijer
Adèle C Green
University of Manchester · GBLeiden University Medical Center · NLQIMR Berghofer Medical Research Institute · AU

Funding

Medical Research Council 89912Medical Research Council G0802468Medical Research Council G0802468(89912)
6 · The paper itself

Abstract

backgroundDespite numerous case reports, epidemiologic evidence regarding true rate of skin cancer in scars of any etiology is sparse.

methodsSystematic literature review of all published epidemiologic studies on skin cancer in scar tissue from surgery, ulcers, or burns using citation databases and manual review.

resultsThere were no epidemiologic data to quantify risk of skin cancer in surgical scars or chronic ulcers. Two eligible cohort studies were identified, from Denmark and Sweden, in which skin cancers in 16, 903 and 37,095 burn patients, respectively, were ascertained through cancer registry follow-up. Each reported standardized incidence ratios (SIRs) for skin cancer types on any site that were uniformly less than unity compared with the general population. Only the Danish cohort assessed skin cancers specifically on past burn injury sites and found a burn-site-specific SIR of 1.2 (95% confidence interval (CI)=0.4-2.7) for squamous cell carcinoma (SCC), 0.7 (95% CI=0.4-1.1) for basal cell carcinoma, and 0.3 (95% CI=0.0-1.2) for melanoma.

conclusionsAvailable epidemiologic data suggest that burn patients are not at higher risk of skin cancers in general, although a modest excess of SCC in burn scars cannot be excluded, nor can excess risk with longer follow-up. Risk of skin cancer in scars other than burn scars has not been investigated epidemiologically.

Indexed as

BurnsCicatrixDenmarkHumansIncidenceRiskSkin NeoplasmsSweden

Identifiers

PMID21635634
PMCPMC3447738
OpenAlexW2085312863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.