ArticleAlcoholism, clinical and experimental research2011
Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample.
Article in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Genetic influences on alcohol sensitivity: A critical review.Current addiction reports · 2024Article
- Gastroprotective mechanism of modified lvdou gancao decoction on ethanol-induced gastric lesions in mice: Involvement of Nrf-2/HO-1/NF-κB signaling pathway.Frontiers in pharmacology · 2022Article
- Endorsement of the "firewater myth" affects the use of protective behavioral strategies among American Indian and Alaska Native students.Addictive behaviors · 2019Article
- Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.Alcoholism, clinical and experimental research · 2018Review
- Association of belief in the "firewater myth" with strategies to avoid alcohol consequences among American Indian and Alaska Native college students who drink.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018Article
- Spatial Epidemiology of Alcohol- and Drug-Related Health Problems Among Northern Plains American Indians: Nebraska and South Dakota, 2007 to 2012.Alcoholism, clinical and experimental research · 2018Article
- Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence.Alcoholism, clinical and experimental research · 2017Article
- Association of the firewater myth with drinking behavior among American Indian and Alaska Native college students.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2016Article
- Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample.Drug and alcohol dependence · 2016Article
- Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.Alcohol research : current reviews · 2016Review
- Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015Article
- Protective variant associated with alcohol dependence in a Mexican American cohort.BMC medical genetics · 2014Article
- Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria.Journal of studies on alcohol and drugs · 2014Article
- The Genetics, Neurogenetics and Pharmacogenetics of Addiction.Current behavioral neuroscience reports · 2014Article
- Repeated diagnoses of lifetime alcohol use disorders in a prospective study: insights into the extent and nature of the reliability and validity problem.Alcoholism, clinical and experimental research · 2014Article
- Rodent models of genetic contributions to motivation to abuse alcohol.Nebraska Symposium on Motivation. Nebraska Symposium on Motivation · 2014Review
- Measuring historical trauma in an American Indian community sample: contributions of substance dependence, affective disorder, conduct disorder and PTSD.Drug and alcohol dependence · 2013Article
- Evidence for a genetic component for substance dependence in Native Americans.The American journal of psychiatry · 2013Review
- Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD.Journal of psychiatric research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious linkage studies, including a study of the Native American population described in the present report, have provided evidence for linkage of alcohol dependence and related traits to chromosome 4q near a cluster of alcohol dehydrogenase (ADH) genes, which encode enzymes of alcohol metabolism.
methodsThe present study tested for associations between alcohol dependence and related traits and 22 single-nucleotide polymorphisms (SNPs) spanning the 7 ADH genes. Participants included 586 adult men and women recruited from 8 contiguous Native American reservations. A structured interview was used to assess DSM-III-R alcohol dependence criteria as well as a set of severe alcohol misuse symptoms and alcohol withdrawal symptoms.
resultsNo evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively). Further, a haplotype analysis of these 2 SNPs suggested that the haplotypes containing either of the minor alleles were protective against alcohol withdrawal relative to the ancestral haplotype (p = 0.000006).
conclusionsThese results suggest that variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence.
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