ArticleThe Journal of pharmacy and pharmacology2011
Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison.
Article in The Journal of pharmacy and pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Sulfation and Its Effect on the Bioactivity of Magnolol, the Main Active Ingredient ofMetabolites · 2022Article
- Metabolism and Pharmacokinetics of SP-8356, a Novel (1Molecules (Basel, Switzerland) · 2020Article
- Pharmacokinetics of B-Ring Unsubstituted Flavones.Pharmaceutics · 2019Review
- Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases.European journal of nutrition · 2018Review
- Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies.The Journal of pharmacy and pharmacology · 2017Article
- Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway.Molecular nutrition & food research · 2016Article
- High accuracy in silico sulfotransferase models.The Journal of biological chemistry · 2013Article
- Designing Endocrine Disruption Out of the Next Generation of Chemicals.Green chemistry : an international journal and green chemistry resource : GC · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesSulfation via sulfotransferases is an important metabolic pathway contributing to the low bioavailability of flavonoids. This study aims to characterize the sulfation of mono-hydroxyflavones (MHFs) to obtain useful information on structure-metabolizing relationships in animal species and gender differences.
methodsThree representative MHFs, namely, 7-, 6- and 4'-MHF, were studied by incubating each MHF at different concentrations with various liver S9 fractions (mouse, rat, dog and human). KEY
findingsOne mono-sulfate was identified for each MHF. 7-MHF and 4'-MHF usually have greater sulfations than 6-MHF. Regardless of whether the S9 fraction came from a male or female, there was a difference in sulfation in the species observed for all MHFs; the highest activity of sulfotransferases was in dog S9. Furthermore, gender differences affect sulfation of MHFs significantly. In rats, all sulfations for the three MHFs were higher in males than that in females while the opposite was observed in mice.
conclusionsRegiospecific, species and gender dependence exist in the sulfonation of all selected MHFs.
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Registered trials
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