ArticleImmunology2011
T regulatory cells participate in the control of germinal centre reactions.
Article in Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- T Regulatory Mechanisms in Airway and Interstitial Lung Disease.Seminars in respiratory and critical care medicine · 2025Review
- Increased Frequency of CD4Cells · 2022Article
- Identification of Follicular T-Cell Subsets in Murine and Human Tissues.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Frontiers of Autoantibodies in Autoimmune Disorders: Crosstalk Between Tfh/Tfr and Regulatory B Cells.Frontiers in immunology · 2021Review
- E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.The Journal of clinical investigation · 2020Article
- Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction.Scientific reports · 2019Article
- Roles of T Follicular Helper Cells and T Follicular Regulatory Cells in Autoantibody Production in IL-2-Deficient Mice.ImmunoHorizons · 2019Article
- Review
- TFrontiers in immunology · 2019Review
- T Cell Subsets in the Germinal Center: Lessons from the Macaque Model.Frontiers in immunology · 2018Review
- CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes.Frontiers in immunology · 2018Article
- Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions.Frontiers in immunology · 2018Review
- T Follicular Helper Cells in Autoimmune Disorders.Frontiers in immunology · 2018Review
- Regulatory T Cells As Potential Targets for HIV Cure Research.Frontiers in immunology · 2018Review
- T follicular regulatory cells in mice and men.Immunology · 2017Review
- Thymic Germinal Centers and Corticosteroids in Myasthenia Gravis: an Immunopathological Study in 1035 Cases and a Critical Review.Clinical reviews in allergy & immunology · 2017Review
- The role of sildenafil in the development of transplant arteriosclerosis in rat aortic grafts.American journal of translational research · 2017Article
- T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Cytokines in the Germinal Center Niche.Antibodies (Basel, Switzerland) · 2016Review
- Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Germinal centre (GC) reactions are central features of T-cell-driven B-cell responses, and the site where antibody-producing cells and memory B cells are generated. Within GCs, a range of complex cellular and molecular events occur which are critical for the generation of high affinity antibodies. These processes require exquisite regulation not only to ensure the production of desired antibodies, but to minimize unwanted autoreactive or low affinity antibodies. To assess whether T regulatory (Treg) cells participate in the control of GC responses, immunized mice were treated with an anti-glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) monoclonal antibody (mAb) to disrupt Treg-cell activity. In anti-GITR-treated mice, the GC B-cell pool was significantly larger compared with control-treated animals, with switched GC B cells composing an abnormally high proportion of the response. Dysregulated GCs were also observed regardless of strain, T helper type 1 or 2 polarizing antigens, and were also seen after anti-CD25 mAb treatment. Within the spleens of immunized mice, CXCR5(+) and CCR7(-) Treg cells were documented by flow cytometry and Foxp3(+) cells were found within GCs using immunohistology. Final studies demonstrated administration of either anti-transforming growth factor-β or anti-interleukin-10 receptor blocking mAb to likewise result in dysregulated GCs, suggesting that generation of inducible Treg cells is important in controlling the GC response. Taken together, these findings indicate that Treg cells contribute to the overall size and quality of the humoral response by controlling homeostasis within GCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.