ArticleBiomacromolecules2011
Synthesis of folate-functionalized RAFT polymers for targeted siRNA delivery.
Article in Biomacromolecules, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Polymeric Nanoparticles for Drug Delivery.Chemical reviews · 2024Review
- RAFT polymer cross-coupling with boronic acids.Chemical science · 2018Article
- Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2018Review
- Article
- Fracture-Targeted Delivery of β-Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture Healing.ACS nano · 2017Article
- Revisiting the value of competition assays in folate receptor-mediated drug delivery.Biomaterials · 2017Article
- Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing.Biomaterials · 2017Article
- Evaluating side effects of nanoparticle-mediated siRNA delivery to mesenchymal stem cells using next generation sequencing and enrichment analysis.Bioengineering & translational medicine · 2016Article
- Folate receptor-targeted aminoglycoside-derived polymers for transgene expression in cancer cells.Bioengineering & translational medicine · 2016Article
- Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms.Journal of materials chemistry. B · 2016Article
- Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance.Biomacromolecules · 2016Article
- pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence.ACS nano · 2015Article
- Dual MMP7-proximity-activated and folate receptor-targeted nanoparticles for siRNA delivery.Biomacromolecules · 2015Article
- Macrophage-specific RNA interference targeting via "click", mannosylated polymeric micelles.Molecular pharmaceutics · 2013Article
- Controlling mesenchymal stem cell gene expression using polymer-mediated delivery of siRNA.Biomacromolecules · 2012Article
- Application of living free radical polymerization for nucleic acid delivery.Accounts of chemical research · 2012Article
- Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures.Journal of cellular biochemistry · 2012Article
- Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery.ACS nano · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Receptor-mediated, cell-specific delivery of siRNA enables silencing of target genes in specific tissues, opening the door to powerful therapeutic options for a multitude of diseases. However, the development of delivery systems capable of targeted and effective siRNA delivery typically requires multiple steps and the use of sophisticated, orthogonal chemistries. Previously, we developed diblock copolymers consisting of dimethaminoethyl methacrylate-b-dimethylaminoethyl methacrylate-co-butyl methacrylate-co-propylacrylic acid as potent siRNA delivery systems that protect siRNA from enzymatic degradation and enable its cytosolic delivery through pH-responsive, endosomolytic behavior. (1, 2) These architectures were polymerized using a living radical polymerization method, specifically reversible addition-fragmentation chain transfer (RAFT) polymerization, which employs a chain transfer agent (CTA) to modulate the rate of reaction, resulting in polymers with low polydispersity and telechelic chain ends reflecting the chemistry of the CTA. Here we describe the straightforward, facile synthesis of a folate receptor-targeted diblock copolymer siRNA delivery system because the folate receptor is an attractive target for tumor-selective therapies as a result of its overexpression in a number of cancers. Specifically, we detail the de novo synthesis of a folate-functionalized CTA, use the folate-CTA for controlled polymerizations of diblock copolymers, and demonstrate efficient, specific cellular folate receptor interaction and in vitro gene knockdown using the folate-functionalized polymer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.