ArticleMolecular biology reports2012
The apoptosis inhibitor survivin prevents insect midgut from cell death during postembryonic development.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone.Insects · 2023Review
- Inhibition of survivin induces spindle disorganization, chromosome misalignment, and DNA damage during mouse embryo development.Cell cycle (Georgetown, Tex.) · 2020Article
- Evaluation of inhibitor of apoptosis genes as targets for RNAi-mediated control of insect pests.Archives of insect biochemistry and physiology · 2020Article
- Cell death during complete metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The programmed cell death (PCD) is important in maintaining the cell number homoeostasis of tissues and organs in metazoan. This process is regulated by the inhibitors of apoptosis proteins (IAPs). The function and mechanism of IAPs have been well studied in animal embryonic development and human cancers. However, the roles and hormonal regulation of IAPs in the postembryonic development are not well understood. We report that an IAP survivin (Ha-survivin) played roles in the postembryonic development of the midgut in a lepidopteran insect Helicoverpa armigera. Ha-survivin was transcribed not only in the embryo, but also in the haemocytes, fat body and midgut during larval molting or pupal adulting. The transcription of Ha-survivin was upregulated by the steroid hormone 20-hydroxyecdysone (20E). Ha-survivin was located in the embryonic cells around the periplasm of the eggs during embryonic development. It was also located in the epithelium cells of the midgut in the fifth molting larvae and later pupae. Knockdown of Ha-survivin by RNAi in the epidermal cell line caused cell apoptosis. These results indicated that Ha-survivin played roles not only in the embryonic development, but also in the postembryonic tissue development by preventing cell death.
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Registered trials
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