ArticleMolecular biology reports2012
Genetic variability of the coding region for the prion protein gene (PRNP) in gayal (Bos frontalis).
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- A comprehensive review on Mithun (Bos frontalis): a keystone species in sustainable livelihoods of the eastern Himalayas and Indo-Burma region.Tropical animal health and production · 2026Review
- De novo transcriptome assembly and annotation of the semi-wild Gayal (Bos frontalis).Scientific data · 2025Article
- First Report of Polymorphisms and Genetic Characteristics ofAnimals : an open access journal from MDPI · 2024Article
- The first report of polymorphisms of the prion protein gene (Frontiers in veterinary science · 2023Article
- Whole genome sequence and de novo assembly revealed genomic architecture of Indian Mithun (Bos frontalis).BMC genomics · 2019Article
- Deletion/insertion polymorphisms of the prion protein gene (Journal of genetics · 2018Article
- Nucleotide diversity of the melanocortin 1 receptor gene (MC1R) in the gayal (Bos frontalis).Molecular biology reports · 2012Article
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The gayal (Bos frontalis) is a rare semi-wild bovid species in which bovine spongiform encephalopathy (BSE) has not been reported. Polymorphisms of the prion protein gene (PRNP) have been correlated significantly with resistance to BSE. In this study, the coding region of PRNP was cloned and characterized in samples from 125 gayal. A total of ten single nucleotide polymorphisms (SNPs), including six silent mutations (C60T, G75A, A108T, G126A, C357T and C678T) and four mis-sense mutations (C8A, G145A, G461A and C756G), corresponding to amino acids T3K, G49S9, N154S and I252M were identified, revealing high genetic diversity. Three novel SNPs including C60T, G145A and C756G, which have not been reported previously in bovid species, were retrieved. There also was one insertion-deletion (187Del24) at the N-terminal octapeptide repeat region. Alignment of nucleotide and amino acid sequences showed a high degree of similarity with other bovid species. Using phylogenetic analyses it was revealed that gayal has a close genetic relationship with Zebu cattle. In short, preliminary information is provided about genotypes of the PRNP in gayal. This could assist with the study of the pathogenesis of transmissible spongiform encephalopathies and cross species transmission as well as a molecular breeding project for gayal in China.
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