ArticleThe open orthopaedics journal2011
Expression of vascular endothelial growth factor on chondrocytes increases with osteoarthritis - an animal experimental investigation.
Article in The open orthopaedics journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- The effect of vascular endothelial growth factor (VEGF) on mouse condylar articular cartilage cultured in vitro.International journal of clinical and experimental pathology · 2018Article
- Significance of new blood vessels in the pathogenesis of temporomandibular joint osteoarthritis.Experimental and therapeutic medicine · 2017Article
- A novel rabbit model of early osteoarthritis exhibits gradual cartilage degeneration after medial collateral ligament transection outside the joint capsule.Scientific reports · 2016Article
- Injecting vascular endothelial growth factor into the temporomandibular joint induces osteoarthritis in mice.Scientific reports · 2015Article
- Relationship of plasma and synovial fluid vascular endothelial growth factor with radiographic severity in primary knee osteoarthritis.International orthopaedics · 2014Article
- Nutrition and degeneration of articular cartilage.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the expression of VEGF by chondrocytes of hyaline cartilage during the course of osteoarthritis (OA).
methodsIn 12 white New Zealand rabbits the anterior cruciate ligament (ACL) was resected to create an anterior instability of the knee. In 12 control rabbits only a sham operation without resection of the ACL was done. Four animals of each group were killed at 3, 6, and 12 weeks. The load bearing area was evaluated histologically according to Mankin and by immunostaining for VEGF.
resultsIn the experimental group, histological grades of OA showed a positive linear correlation with the time after surgery. Immunostaining showed an increased expression of VEGF in the control group after 3 weeks, which dropped to normal after 6 weeks. There was no difference in the progression of OA between control and experimental groups after 3 weeks, but a significant difference was seen after 6 (p=0,01) and 12 (p=0,05) weeks. A significant positive correlation between VEGF expression and the histological grade of OA was found (r = 0.767; p<0.01).
conclusionsAn increase of VEGF expressing chondrocytes occurs during time course of OA.
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