Evidence map›Paper›PMID 21633657›Full record

ReviewWorld journal of gastroenterology2011

Role of lipid rafts in liver health and disease.

Angela Dolganiuc

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Biomimetic delivery with micro- and nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2012
    Review
  9. Article
  10. An annual topic highlight: alcohol and liver, 2011.World journal of gastroenterology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Angela DolganiucDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States. angela.dolganiuc@umassmed.edu

Funding

Acute alcohol and calcium-dependent LPS-triggered activation of macrophagesR01AA017212 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DOLGANIUC, ANGELA · 2009 to 2013
$1.7M
Alcohol disrupts TLR4 signaling in lipid raftsR21AA016571 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DOLGANIUC, ANGELA · 2007 to 2008
$427k
NIAAA NIH HHS AA016571NIAAA NIH HHS R01 AA017212NIAAA NIH HHS R21 AA016571
6 · The paper itself

Abstract

Liver diseases are an increasingly common cause of morbidity and mortality; new approaches for investigation of mechanisms of liver diseases and identification of therapeutic targets are emergent. Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver cells, parenchymal and non-parenchymal; more importantly, LRs are active participants in multiple physiological and pathological conditions in individual types of liver cells. This article aims to review experimental-based evidence with regard to LRs in the liver, from the perspective of the liver as a whole organ composed of a multitude of cell types. We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases.

Indexed as

AnimalsCell DeathCell MembraneHumansLiverLiver DiseasesMembrane MicrodomainsSignal TransductionEndothelial cellsHepatitis C virusHepatocytesKupffer cellsMetabolismSignalingStellate cellsTherapeuticViral

Identifiers

PMID21633657
PMCPMC3103810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.