ArticleWorld journal of gastroenterology2011
Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Oral tolerance is inducible during active dextran sulfate sodium-induced colitis.World journal of gastrointestinal pharmacology and therapeutics · 2016Article
- New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation.PloS one · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
aimTo evaluate the concomitant effects of appendectomy and oral tolerance on colitis.
methodsDelayed-type hypersensitivity (DTH) was investigated at a 7-d interval after ovalbumin (OVA) administration and immunization under normal and colitis conditions in appendectomized or sham-operated mice. Pathological scores for the colon were graded after ingestion of colon-extracted protein (CEP) and induction of dextran sulfate sodium (DSS) colitis in appendectomized or sham-operated mice. Thereafter, Th1 and Th2 in Peyer's patches and spleen lymphocytes were detected in CEP-treated and bovine serum albumin (BSA)-treated control mice.
resultsIn appendectomized mice, DTH was not inhibited at day 7 after OVA administration and at the initial phase of DSS colitis, whereas it was inhibited at day 14 and day 21. However, in sham-operated mice, it was inhibited during the whole procedure and the onset of DSS colitis. The protective role of CEP against DSS colitis was present in sham-operated mice, with predominant improvement of colonic pathological changes, while vanished in the appendectomized mice. A shift from Th1 to Th2 in Peyer's patches resulted from a decrease of Th1 cells with the ingestion of CEP. Compared with BSA in the sham-operated group, no predominant changes were observed in the appendectomized mice.
conclusionAppendectomy interferes with the protective role of CEP in DSS colitis via a shift from Th2 to Th1 during oral tolerance induction.
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