ArticlePloS one2011
Novel insights into the diversity of catabolic metabolism from ten haloarchaeal genomes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 76 citations in OpenAlex.
- Elucidating metabolic pathways through genomic analysis in highly heavy metal-resistantHeliyon · 2024Article
- The biosynthesis mechanism of bacterioruberin in halophilic archaea revealed by genome and transcriptome analysis.Applied and environmental microbiology · 2024Article
- Dynamic evolution of the mTHF gene family associated with primary metabolism across life.BMC genomics · 2024Article
- A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities.PLoS genetics · 2024Article
- Nanohaloarchaea as beneficiaries of xylan degradation by haloarchaea.Microbial biotechnology · 2023Article
- Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications.Frontiers in microbiology · 2023Review
- The biology of thermoacidophilic archaea from the order Sulfolobales.FEMS microbiology reviews · 2021Article
- Archaea: An Agro-Ecological Perspective.Current microbiology · 2021Review
- Open Issues for Protein Function Assignment inGenes · 2021Article
- Halophilic archaea and their potential to generate renewable fuels and chemicals.Biotechnology and bioengineering · 2021Review
- Genomic Insights Into New Species of the GenusFrontiers in microbiology · 2021Article
- Pentose degradation in archaea: Halorhabdus species degrade D-xylose, L-arabinose and D-ribose via bacterial-type pathways.Extremophiles : life under extreme conditions · 2020Article
- Biochemical and Taxonomic Characterization of Novel Haloarchaeal Strains and Purification of the Recombinant Halotolerant α-Amylase Discovered in the Isolate.Frontiers in microbiology · 2020Article
- Sucrose Metabolism in Haloarchaea: Reassessment Using Genomics, Proteomics, and Metagenomics.Applied and environmental microbiology · 2019Article
- NewFrontiers in microbiology · 2019Article
- Archaeal biofilm formation.Nature reviews. Microbiology · 2018Review
- Phylogenomics of Rhodobacteraceae reveals evolutionary adaptation to marine and non-marine habitats.The ISME journal · 2017Article
- Structural characterization of amphiphilic siderophores produced by a soda lake isolate, Halomonas sp. SL01, reveals cysteine-, phenylalanine- and proline-containing head groups.Extremophiles : life under extreme conditions · 2015Article
- A taxonomic framework for emerging groups of ecologically important marine gammaproteobacteria based on the reconstruction of evolutionary relationships using genome-scale data.Frontiers in microbiology · 2015Article
- Microbial ecology of an Antarctic hypersaline lake: genomic assessment of ecophysiology among dominant haloarchaea.The ISME journal · 2014Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe extremely halophilic archaea are present worldwide in saline environments and have important biotechnological applications. Ten complete genomes of haloarchaea are now available, providing an opportunity for comparative analysis. METHODOLOGY/PRINCIPAL
findingsWe report here the comparative analysis of five newly sequenced haloarchaeal genomes with five previously published ones. Whole genome trees based on protein sequences provide strong support for deep relationships between the ten organisms. Using a soft clustering approach, we identified 887 protein clusters present in all halophiles. Of these core clusters, 112 are not found in any other archaea and therefore constitute the haloarchaeal signature. Four of the halophiles were isolated from water, and four were isolated from soil or sediment. Although there are few habitat-specific clusters, the soil/sediment halophiles tend to have greater capacity for polysaccharide degradation, siderophore synthesis, and cell wall modification. Halorhabdus utahensis and Haloterrigena turkmenica encode over forty glycosyl hydrolases each, and may be capable of breaking down naturally occurring complex carbohydrates. H. utahensis is specialized for growth on carbohydrates and has few amino acid degradation pathways. It uses the non-oxidative pentose phosphate pathway instead of the oxidative pathway, giving it more flexibility in the metabolism of pentoses.
conclusionsThese new genomes expand our understanding of haloarchaeal catabolic pathways, providing a basis for further experimental analysis, especially with regard to carbohydrate metabolism. Halophilic glycosyl hydrolases for use in biofuel production are more likely to be found in halophiles isolated from soil or sediment.
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