ArticleThe American journal of tropical medicine and hygiene2011
Analysis of the cross-reactivity of various 56 kDa recombinant protein antigens with serum samples collected after Orientia tsutsugamushi infection by ELISA.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- In silico prediction of Gallibacterium anatis pan-immunogens.Veterinary research · 2014Trial
- Estimating the Seroprevalence of Scrub Typhus in Nepal.Pathogens (Basel, Switzerland) · 2024Article
- A Use of 56-kDa Recombinant Protein ofTropical medicine and infectious disease · 2022Article
- Development of a Scrub Typhus Diagnostic Platform Incorporating Cell-Surface Display Technology.Frontiers in immunology · 2021Article
- Diagnosis of scrub typhus: recent advancements and challenges.3 Biotech · 2020Review
- Evaluation of Enzyme-Linked Immunosorbent Assay Using Recombinant 56-kDa Type-Specific Antigens Derived from MultipleThe American journal of tropical medicine and hygiene · 2019Article
- An ELISA assay using a combination of recombinant proteins from multiple strains of Orientia tsutsugamushi offers an accurate diagnosis for scrub typhus.BMC infectious diseases · 2017Article
- Optimal Cutoff and Accuracy of an IgM Enzyme-Linked Immunosorbent Assay for Diagnosis of Acute Scrub Typhus in Northern Thailand: an Alternative Reference Method to the IgM Immunofluorescence Assay.Journal of clinical microbiology · 2016Article
- Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand.PLoS neglected tropical diseases · 2016Article
- Dot-ELISA Rapid Test Using Recombinant 56-kDa Protein Antigens for Serodiagnosis of Scrub Typhus.The American journal of tropical medicine and hygiene · 2015Article
- Microarray of surface-exposed proteins of Rickettsia heilongjiangensis for serodiagnosis of Far-eastern spotted fever.BMC infectious diseases · 2014Article
- Cloning, expression, and immunocharacterization of surface protein containing an altered thrombospondin repeat domain (SPATR) from Plasmodium knowlesi.Malaria journal · 2013Article
- Development of new, broadly reactive, rapid IgG and IgM lateral flow assays for diagnosis of scrub typhus.The American journal of tropical medicine and hygiene · 2012Article
- Scrub Typhus: An Emerging Threat.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orientia tsutsugamushi, the etiologic agent of scrub typhus, has a highly expressed and immunodominant 56-kD outer membrane protein. This protein is one of the leading candidates for diagnosis and vaccine development for scrub typhus. Previous studies using recombinant 56-kD protein (r56s) derived from Karp strain (Kpr56) in a mouse model have shown good homologous protection but only moderate to poor heterologous protection. We evaluated the cross-reactivity of recombinant 56-kD proteins from Karp, Kato, Gilliam, TA763, and three chimeric 56-kD proteins. Not all r56s are equally reactive with strain-specific serum samples. These data provide a first glance of how reactive these r56s are toward the antiserum of different strains and which r56 exhibits the broadest reactivity. A formulation of this combination has the potential to provide broad protection against the heterologous challenge and to be used in a highly sensitive diagnostic assay.
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